{"id":"oprm1","name":"Mu-opioid receptor","symbol":"OPRM1","route":"/targets/oprm1/","asOf":"2026-09-04","xrefs":[{"hgnc":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8156","ensembl":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000112038","uniprot":"https://www.uniprot.org/uniprotkb/P35372/entry","alphafold-db":"https://alphafold.ebi.ac.uk/entry/P35372","chembl":"https://www.ebi.ac.uk/chembl/explore/target/CHEMBL233","open-targets":"https://platform.opentargets.org/target/ENSG00000112038","civic":"https://civicdb.org/genes/4988/summary","oncokb":"https://www.oncokb.org/gene/OPRM1","cosmic":"https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=OPRM1","cbioportal":"https://www.cbioportal.org/results/mutations?cancer_study_list=msk_impact_2017&gene_list=OPRM1","depmap":"https://depmap.org/portal/gene/OPRM1?tab=overview","human-protein-atlas":"https://www.proteinatlas.org/ENSG00000112038-OPRM1","ncbi-gene":"https://www.ncbi.nlm.nih.gov/gene/4988","omim":"https://www.omim.org/entry/600018"}],"products":[{"id":"fentanyl","name":"Fentanyl (transmucosal, for breakthrough cancer pain)","status":"approved","modality":"Small-molecule opioid analgesic (buccal tablet and nasal sprays)","route":"/drugs/fentanyl/"},{"id":"methylnaltrexone","name":"Methylnaltrexone","status":"approved","modality":"Peripherally acting mu-opioid receptor antagonist","route":"/drugs/methylnaltrexone/"}],"trials":[{"id":"mntx-302","name":"MNTX 302","nct":"NCT00402038","phase":"3","status":"positive"},{"id":"nct00542542","name":"Evaluate the Use of Paravertebral Block in Reconstructive Breast Surgery","nct":"NCT00542542","phase":"3","status":"completed"}],"pathways":[],"companies":["bausch-health","gruenenthal"],"keyPapers":[],"hotspots":[],"openQuestions":[],"assays":[],"resistance":[],"licence":"CC BY-NC 4.0, attribution to OnCo (https://onco.cc); commercial use needs a licence"}