{"id":"nrg1","name":"NRG1","symbol":"NRG1","route":"/targets/nrg1/","asOf":"2026-09-23","xrefs":[{"hgnc":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7997","ensembl":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000157168","uniprot":"https://www.uniprot.org/uniprotkb/Q02297/entry","alphafold-db":"https://alphafold.ebi.ac.uk/entry/Q02297","open-targets":"https://platform.opentargets.org/target/ENSG00000157168","civic":"https://civicdb.org/genes/3084/summary","oncokb":"https://www.oncokb.org/gene/NRG1","cosmic":"https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=NRG1","cbioportal":"https://www.cbioportal.org/results/mutations?cancer_study_list=msk_impact_2017&gene_list=NRG1","depmap":"https://depmap.org/portal/gene/NRG1?tab=overview","human-protein-atlas":"https://www.proteinatlas.org/ENSG00000157168-NRG1","ncbi-gene":"https://www.ncbi.nlm.nih.gov/gene/3084","omim":"https://www.omim.org/entry/142445"}],"products":[],"trials":[{"id":"nct02912949","name":"A Study of Zenocutuzumab (MCLA-128) in Patients With Solid Tumors Harboring an NRG1 Fusion (eNRGy)","nct":"NCT02912949","phase":"2","status":"active"}],"pathways":[],"companies":[],"keyPapers":["paper-enrgy-zenocutuzumab-nrg1-fusion-positive-cancer-nejm-2025","paper-philip-kras-wild-type-pancreatic-ccr-2022","paper-jonna-nrg1-fusions-solid-tumours-ccr-2019","paper-jones-nrg1-fusions-recurrent-actionable-kras-wild-type-pdac-ccr-2019","paper-heining-nrg1-fusions-kras-wild-type-pancreatic-cancer-discov-2018","paper-fernandez-cuesta-cd74-nrg1-fusion-lung-cancer-discov-2014"],"hotspots":[],"openQuestions":[],"assays":[],"resistance":[],"licence":"CC BY-NC 4.0, attribution to OnCo (https://onco.cc); commercial use needs a licence"}