{"id":"nras","name":"NRAS","symbol":"NRAS","route":"/targets/nras/","asOf":"2026-09-22","xrefs":[{"hgnc":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7989","ensembl":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000213281","uniprot":"https://www.uniprot.org/uniprotkb/P01111/entry","alphafold-db":"https://alphafold.ebi.ac.uk/entry/P01111","chembl":"https://www.ebi.ac.uk/chembl/explore/target/CHEMBL2079845","open-targets":"https://platform.opentargets.org/target/ENSG00000213281","civic":"https://civicdb.org/genes/4893/summary","oncokb":"https://www.oncokb.org/gene/NRAS","cosmic":"https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=NRAS","cbioportal":"https://www.cbioportal.org/results/mutations?cancer_study_list=msk_impact_2017&gene_list=NRAS","depmap":"https://depmap.org/portal/gene/NRAS?tab=overview","human-protein-atlas":"https://www.proteinatlas.org/ENSG00000213281-NRAS","ncbi-gene":"https://www.ncbi.nlm.nih.gov/gene/4893","omim":"https://www.omim.org/entry/164790"}],"products":[{"id":"jyp0015","name":"JYP0015","status":"phase-2","modality":"small molecule (structure undisclosed or not yet in PubChem)","route":"/drugs/jyp0015/"}],"trials":[{"id":"prime","name":"PRIME","nct":"NCT00364013","phase":"3","status":"positive"},{"id":"chronos","name":"CHRONOS","nct":"NCT03227926","phase":"2","status":"positive"},{"id":"nct06895031","name":"Study of JYP0015 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS","nct":"NCT06895031","phase":"2","status":"recruiting"}],"pathways":[],"companies":[],"keyPapers":["paper-paradigm-jama-2023","paper-sepulveda-molecular-biomarkers-colorectal-guideline-jco-2017","paper-arnold-primary-tumour-side-ras-wild-type-ann-oncol-2017","paper-kris-lung-cancer-mutation-consortium-jama-2014","paper-douillard-prime-panitumumab-ras-nejm-2013"],"hotspots":[],"openQuestions":[],"assays":[],"resistance":[],"licence":"CC BY-NC 4.0, attribution to OnCo (https://onco.cc); commercial use needs a licence"}