{"id":"notch1","name":"NOTCH1","symbol":"NOTCH1","route":"/targets/notch1/","asOf":"2026-09-23","xrefs":[{"hgnc":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7881","ensembl":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000148400","uniprot":"https://www.uniprot.org/uniprotkb/P46531/entry","alphafold-db":"https://alphafold.ebi.ac.uk/entry/P46531","open-targets":"https://platform.opentargets.org/target/ENSG00000148400","civic":"https://civicdb.org/genes/4851/summary","oncokb":"https://www.oncokb.org/gene/NOTCH1","cosmic":"https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=NOTCH1","cbioportal":"https://www.cbioportal.org/results/mutations?cancer_study_list=msk_impact_2017&gene_list=NOTCH1","depmap":"https://depmap.org/portal/gene/NOTCH1?tab=overview","human-protein-atlas":"https://www.proteinatlas.org/ENSG00000148400-NOTCH1","ncbi-gene":"https://www.ncbi.nlm.nih.gov/gene/4851","omim":"https://www.omim.org/entry/190198"}],"products":[],"trials":[],"pathways":[],"companies":[],"keyPapers":["paper-erices-chilean-gallbladder-landscape-front-oncol-2025","paper-wright-lymphgen-genetic-subtypes-dlbcl-cancer-cell-2020","paper-schmitz-genetics-pathogenesis-dlbcl-nejm-2018","paper-george-sclc-genomic-profiles-nature-2015","paper-wang-notch-pest-mutations-tnbc-ccr-2015","paper-stoeck-notch-rearrangements-tnbc-cancer-discov-2014","paper-tcga-lung-squamous-nature-2012"],"hotspots":[],"openQuestions":[],"assays":[],"resistance":[],"licence":"CC BY-NC 4.0, attribution to OnCo (https://onco.cc); commercial use needs a licence"}