{"id":"msh2","name":"MSH2","symbol":"MSH2","route":"/targets/msh2/","asOf":"2026-09-23","xrefs":[{"hgnc":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7325","ensembl":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000095002","uniprot":"https://www.uniprot.org/uniprotkb/P43246/entry","alphafold-db":"https://alphafold.ebi.ac.uk/entry/P43246","open-targets":"https://platform.opentargets.org/target/ENSG00000095002","civic":"https://civicdb.org/genes/4436/summary","oncokb":"https://www.oncokb.org/gene/MSH2","cosmic":"https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=MSH2","cbioportal":"https://www.cbioportal.org/results/mutations?cancer_study_list=msk_impact_2017&gene_list=MSH2","depmap":"https://depmap.org/portal/gene/MSH2?tab=overview","human-protein-atlas":"https://www.proteinatlas.org/ENSG00000095002-MSH2","ncbi-gene":"https://www.ncbi.nlm.nih.gov/gene/4436","omim":"https://www.omim.org/entry/609309"}],"products":[],"trials":[],"pathways":[],"companies":[],"keyPapers":["paper-nicolosi-germline-variants-prostate-testing-guidelines-jama-oncol-2019","paper-abida-msi-prostate-checkpoint-blockade-jama-oncol-2019","paper-wardell-biliary-drivers-germline-j-hepatol-2018","paper-hu-mismatch-repair-deficiency-pancreatic-adenocarcinoma-ccr-2018","paper-guedes-msh2-loss-primary-prostate-ccr-2017","paper-pritchard-complex-msh2-msh6-hypermutated-prostate-nat-commun-2014","paper-moreira-lynch-syndrome-identification-jama-2012","paper-ligtenberg-epcam-deletion-msh2-silencing-nat-genet-2009"],"hotspots":[],"openQuestions":[],"assays":[],"resistance":[],"licence":"CC BY-NC 4.0, attribution to OnCo (https://onco.cc); commercial use needs a licence"}