{"id":"mpl","name":"MPL (thrombopoietin receptor)","symbol":"MPL","route":"/targets/mpl/","asOf":"2026-09-22","xrefs":[{"hgnc":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7217","ensembl":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000117400","uniprot":"https://www.uniprot.org/uniprotkb/P40238/entry","alphafold-db":"https://alphafold.ebi.ac.uk/entry/P40238","chembl":"https://www.ebi.ac.uk/chembl/explore/target/CHEMBL1864","open-targets":"https://platform.opentargets.org/target/ENSG00000117400","civic":"https://civicdb.org/genes/4352/summary","oncokb":"https://www.oncokb.org/gene/MPL","cosmic":"https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=MPL","cbioportal":"https://www.cbioportal.org/results/mutations?cancer_study_list=msk_impact_2017&gene_list=MPL","depmap":"https://depmap.org/portal/gene/MPL?tab=overview","human-protein-atlas":"https://www.proteinatlas.org/ENSG00000117400-MPL","ncbi-gene":"https://www.ncbi.nlm.nih.gov/gene/4352","omim":"https://www.omim.org/entry/159530"}],"products":[{"id":"eltrombopag","name":"Eltrombopag","status":"established","modality":"Oral thrombopoietin receptor agonist","route":"/drugs/eltrombopag/"},{"id":"romiplostim","name":"Romiplostim","status":"established","modality":"Thrombopoietin receptor agonist (peptibody), weekly injection","route":"/drugs/romiplostim/"}],"trials":[{"id":"nct03937154","name":"Study of Romiplostim for Chemotherapy-induced Thrombocytopenia in Adult Subjects With Non-small Cell Lung Cancer (NSCLC), Ovarian Cancer, or Breast Cancer","nct":"NCT03937154","phase":"3","status":"active"},{"id":"nct01772420","name":"Phase II Study of Lenalidomide and Eltrombopag in Patients With Symptomatic Anemia","nct":"NCT01772420","phase":"2","status":"completed"},{"id":"nct01890746","name":"A Safety and Efficacy Study of Eltrombopag in Subjects With AML","nct":"NCT01890746","phase":"2","status":"completed"},{"id":"nct03603795","name":"Study Impact on Outcome of Eltrombopag in Elderly Patients with Acute Myeloid Leukemia Receiving Induction Chemotherapy","nct":"NCT03603795","phase":"2","status":"active"}],"pathways":[],"companies":["amgen","novartis"],"keyPapers":[],"hotspots":[],"openQuestions":[],"assays":[],"resistance":[],"licence":"CC BY-NC 4.0, attribution to OnCo (https://onco.cc); commercial use needs a licence"}