{"id":"mlh1","name":"MLH1","symbol":"MLH1","route":"/targets/mlh1/","asOf":"2026-09-23","xrefs":[{"hgnc":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7127","ensembl":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000076242","uniprot":"https://www.uniprot.org/uniprotkb/P40692/entry","alphafold-db":"https://alphafold.ebi.ac.uk/entry/P40692","open-targets":"https://platform.opentargets.org/target/ENSG00000076242","civic":"https://civicdb.org/genes/4292/summary","oncokb":"https://www.oncokb.org/gene/MLH1","cosmic":"https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=MLH1","cbioportal":"https://www.cbioportal.org/results/mutations?cancer_study_list=msk_impact_2017&gene_list=MLH1","depmap":"https://depmap.org/portal/gene/MLH1?tab=overview","human-protein-atlas":"https://www.proteinatlas.org/ENSG00000076242-MLH1","ncbi-gene":"https://www.ncbi.nlm.nih.gov/gene/4292","omim":"https://www.omim.org/entry/120436"}],"products":[],"trials":[],"pathways":[],"companies":[],"keyPapers":["paper-nicolosi-germline-variants-prostate-testing-guidelines-jama-oncol-2019","paper-abida-msi-prostate-checkpoint-blockade-jama-oncol-2019","paper-hu-germline-mutations-pancreatic-cancer-risk-jama-2018","paper-wardell-biliary-drivers-germline-j-hepatol-2018","paper-hu-mismatch-repair-deficiency-pancreatic-adenocarcinoma-ccr-2018","paper-shindo-germline-sporadic-pancreatic-jco-2017","paper-moreira-lynch-syndrome-identification-jama-2012","paper-koopman-deficient-mismatch-repair-advanced-colorectal-bjc-2009","paper-weisenberger-cimp-braf-mlh1-colorectal-nat-genet-2006","paper-herman-mlh1-promoter-hypermethylation-colorectal-pnas-1998"],"hotspots":[],"openQuestions":[],"assays":[],"resistance":[],"licence":"CC BY-NC 4.0, attribution to OnCo (https://onco.cc); commercial use needs a licence"}