{"id":"mage-a4","name":"MAGE-A4","symbol":"MAGEA4","route":"/targets/mage-a4/","asOf":"2026-09-04","xrefs":[{"hgnc":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6802","ensembl":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000147381","uniprot":"https://www.uniprot.org/uniprotkb/P43358/entry","alphafold-db":"https://alphafold.ebi.ac.uk/entry/P43358","chembl":"https://www.ebi.ac.uk/chembl/explore/target/CHEMBL4296022","open-targets":"https://platform.opentargets.org/target/ENSG00000147381","civic":"https://civicdb.org/genes/4103/summary","oncokb":"https://www.oncokb.org/gene/MAGEA4","cosmic":"https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=MAGEA4","cbioportal":"https://www.cbioportal.org/results/mutations?cancer_study_list=msk_impact_2017&gene_list=MAGEA4","depmap":"https://depmap.org/portal/gene/MAGEA4?tab=overview","human-protein-atlas":"https://www.proteinatlas.org/ENSG00000147381-MAGEA4","ncbi-gene":"https://www.ncbi.nlm.nih.gov/gene/4103","omim":"https://www.omim.org/entry/300175"}],"products":[{"id":"afamitresgene-autoleucel","name":"Afamitresgene autoleucel","status":"approved","modality":"TCR-T (MAGE-A4)","route":"/drugs/afamitresgene-autoleucel/"}],"trials":[{"id":"nct04044768","name":"Spearhead 1 Study in Subjects With Advanced Synovial Sarcoma or Myxoid/Round Cell Liposarcoma","nct":"NCT04044768","phase":"2","status":"active"},{"id":"nct05642455","name":"SPEARHEAD-3 Pediatric Study","nct":"NCT05642455","phase":"1/2","status":"recruiting"}],"pathways":[],"companies":["adaptimmune","tscan"],"keyPapers":["paper-spearhead-1-lancet-2024"],"hotspots":[],"openQuestions":[],"assays":[],"resistance":[],"licence":"CC BY-NC 4.0, attribution to OnCo (https://onco.cc); commercial use needs a licence"}