{"id":"keap1","name":"KEAP1","symbol":"KEAP1","route":"/targets/keap1/","asOf":"2026-09-23","xrefs":[{"hgnc":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:23177","ensembl":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000079999","uniprot":"https://www.uniprot.org/uniprotkb/Q14145/entry","alphafold-db":"https://alphafold.ebi.ac.uk/entry/Q14145","open-targets":"https://platform.opentargets.org/target/ENSG00000079999","civic":"https://civicdb.org/genes/9817/summary","oncokb":"https://www.oncokb.org/gene/KEAP1","cosmic":"https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=KEAP1","cbioportal":"https://www.cbioportal.org/results/mutations?cancer_study_list=msk_impact_2017&gene_list=KEAP1","depmap":"https://depmap.org/portal/gene/KEAP1?tab=overview","human-protein-atlas":"https://www.proteinatlas.org/ENSG00000079999-KEAP1","ncbi-gene":"https://www.ncbi.nlm.nih.gov/gene/9817","omim":"https://www.omim.org/entry/606016"}],"products":[],"trials":[],"pathways":[],"companies":[],"keyPapers":["paper-keynote-042-tmb-mutations-ann-oncol-2023","paper-keynote-189-407-tmb-jtocrr-2023","paper-ricciuti-stk11-keap1-kras-immunotherapy-jto-2022","paper-chen-east-asian-lung-adenocarcinoma-nat-genet-2020","paper-pandey-gallbladder-elf3-nat-commun-2020","paper-schoenfeld-smarca4-alterations-lung-ccr-2020","paper-arbour-kras-co-mutation-outcomes-ccr-2018","paper-kras-nsclc-cancer-discov-2018","paper-jordan-prospective-lung-adenocarcinoma-msk-cancer-discov-2017","paper-skoulidis-kras-co-mutation-subsets-cancer-discov-2015","paper-tcga-lung-adenocarcinoma-nature-2014","paper-tcga-lung-squamous-nature-2012"],"hotspots":[],"openQuestions":[],"assays":[],"resistance":[],"licence":"CC BY-NC 4.0, attribution to OnCo (https://onco.cc); commercial use needs a licence"}