{"id":"gamma-secretase","name":"Gamma-secretase (PSEN1)","symbol":"PSEN1","route":"/targets/gamma-secretase/","asOf":"2026-09-04","xrefs":[{"hgnc":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9508","ensembl":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000080815","uniprot":"https://www.uniprot.org/uniprotkb/P49768/entry","alphafold-db":"https://alphafold.ebi.ac.uk/entry/P49768","chembl":"https://www.ebi.ac.uk/chembl/explore/target/CHEMBL2473","open-targets":"https://platform.opentargets.org/target/ENSG00000080815","civic":"https://civicdb.org/genes/5663/summary","oncokb":"https://www.oncokb.org/gene/PSEN1","cosmic":"https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=PSEN1","cbioportal":"https://www.cbioportal.org/results/mutations?cancer_study_list=msk_impact_2017&gene_list=PSEN1","depmap":"https://depmap.org/portal/gene/PSEN1?tab=overview","human-protein-atlas":"https://www.proteinatlas.org/ENSG00000080815-PSEN1","ncbi-gene":"https://www.ncbi.nlm.nih.gov/gene/5663","omim":"https://www.omim.org/entry/104311"}],"products":[],"trials":[],"pathways":[],"companies":["immunome"],"keyPapers":["paper-wang-notch-pest-mutations-tnbc-ccr-2015","paper-stoeck-notch-rearrangements-tnbc-cancer-discov-2014"],"hotspots":[],"openQuestions":[],"assays":[],"resistance":[],"licence":"CC BY-NC 4.0, attribution to OnCo (https://onco.cc); commercial use needs a licence"}