{"id":"ewsr1-fli1","name":"EWSR1-FLI1 fusion","symbol":"EWSR1::FLI1","route":"/targets/ewsr1-fli1/","asOf":"2026-09-08","xrefs":[{"hgnc":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3508","ensembl":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000182944","uniprot":"https://www.uniprot.org/uniprotkb/Q01844/entry","alphafold-db":"https://alphafold.ebi.ac.uk/entry/Q01844","chembl":"https://www.ebi.ac.uk/chembl/explore/target/CHEMBL3351202","open-targets":"https://platform.opentargets.org/target/ENSG00000182944","civic":"https://civicdb.org/genes/2130/summary","oncokb":"https://www.oncokb.org/gene/EWSR1","cosmic":"https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=EWSR1","cbioportal":"https://www.cbioportal.org/results/mutations?cancer_study_list=msk_impact_2017&gene_list=EWSR1","depmap":"https://depmap.org/portal/gene/EWSR1?tab=overview","human-protein-atlas":"https://www.proteinatlas.org/ENSG00000182944-EWSR1","ncbi-gene":"https://www.ncbi.nlm.nih.gov/gene/2130","omim":"https://www.omim.org/entry/133450"},{"hgnc":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3749","ensembl":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000151702","uniprot":"https://www.uniprot.org/uniprotkb/Q01543/entry","alphafold-db":"https://alphafold.ebi.ac.uk/entry/Q01543","chembl":"https://www.ebi.ac.uk/chembl/explore/target/CHEMBL5465299","open-targets":"https://platform.opentargets.org/target/ENSG00000151702","civic":"https://civicdb.org/genes/2313/summary","oncokb":"https://www.oncokb.org/gene/FLI1","cosmic":"https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=FLI1","cbioportal":"https://www.cbioportal.org/results/mutations?cancer_study_list=msk_impact_2017&gene_list=FLI1","depmap":"https://depmap.org/portal/gene/FLI1?tab=overview","human-protein-atlas":"https://www.proteinatlas.org/ENSG00000151702-FLI1","ncbi-gene":"https://www.ncbi.nlm.nih.gov/gene/2313","omim":"https://www.omim.org/entry/193067"}],"products":[{"id":"tk216","name":"TK216","status":"phase-2","modality":"Small-molecule EWS-FLI1 inhibitor","route":"/drugs/tk216/"}],"trials":[],"pathways":["transcription-addiction"],"companies":["oncternal-therapeutics"],"keyPapers":["paper-delattre-nature"],"hotspots":[],"openQuestions":[],"assays":[],"resistance":[],"licence":"CC BY-NC 4.0, attribution to OnCo (https://onco.cc); commercial use needs a licence"}