{"id":"cyp17a1","name":"CYP17A1 (17-alpha-hydroxylase/17,20-lyase)","symbol":"CYP17A1","route":"/targets/cyp17a1/","asOf":"2026-09-04","xrefs":[{"hgnc":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2593","ensembl":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000148795","uniprot":"https://www.uniprot.org/uniprotkb/P05093/entry","alphafold-db":"https://alphafold.ebi.ac.uk/entry/P05093","chembl":"https://www.ebi.ac.uk/chembl/explore/target/CHEMBL3522","open-targets":"https://platform.opentargets.org/target/ENSG00000148795","civic":"https://civicdb.org/genes/1586/summary","oncokb":"https://www.oncokb.org/gene/CYP17A1","cosmic":"https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=CYP17A1","cbioportal":"https://www.cbioportal.org/results/mutations?cancer_study_list=msk_impact_2017&gene_list=CYP17A1","depmap":"https://depmap.org/portal/gene/CYP17A1?tab=overview","human-protein-atlas":"https://www.proteinatlas.org/ENSG00000148795-CYP17A1","ncbi-gene":"https://www.ncbi.nlm.nih.gov/gene/1586","omim":"https://www.omim.org/entry/609300"}],"products":[{"id":"galeterone","name":"Galeterone","status":"withdrawn","modality":"small molecule","route":"/drugs/galeterone/"},{"id":"orteronel","name":"Orteronel","status":"withdrawn","modality":"small molecule","route":"/drugs/orteronel/"}],"trials":[{"id":"armor3-sv","name":"ARMOR3-SV","nct":"NCT02438007","phase":"3","status":"negative"},{"id":"elm-pc-4-orteronel","name":"ELM-PC 4","nct":"NCT01193244","phase":"3","status":"negative"}],"pathways":[],"companies":["takeda"],"keyPapers":[],"hotspots":[],"openQuestions":[],"assays":[],"resistance":[],"licence":"CC BY-NC 4.0, attribution to OnCo (https://onco.cc); commercial use needs a licence"}