{"id":"ciita","name":"CIITA","symbol":"CIITA","route":"/targets/ciita/","asOf":"2026-09-23","xrefs":[{"hgnc":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7067","ensembl":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000179583","uniprot":"https://www.uniprot.org/uniprotkb/P33076/entry","alphafold-db":"https://alphafold.ebi.ac.uk/entry/P33076","open-targets":"https://platform.opentargets.org/target/ENSG00000179583","civic":"https://civicdb.org/genes/4261/summary","oncokb":"https://www.oncokb.org/gene/CIITA","cosmic":"https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=CIITA","cbioportal":"https://www.cbioportal.org/results/mutations?cancer_study_list=msk_impact_2017&gene_list=CIITA","depmap":"https://depmap.org/portal/gene/CIITA?tab=overview","human-protein-atlas":"https://www.proteinatlas.org/ENSG00000179583-CIITA","ncbi-gene":"https://www.ncbi.nlm.nih.gov/gene/4261","omim":"https://www.omim.org/entry/600005"}],"products":[],"trials":[],"pathways":[],"companies":[],"keyPapers":[],"hotspots":[],"openQuestions":[],"assays":[],"resistance":[{"class":"pd1-hodgkin","mechanism":"Loss of MHC class II on the Reed-Sternberg cell","category":"immune-evasion"},{"class":"pd1-hodgkin","mechanism":"CIITA rearrangement","category":"immune-evasion"}],"licence":"CC BY-NC 4.0, attribution to OnCo (https://onco.cc); commercial use needs a licence"}