{"id":"chek2","name":"CHEK2","symbol":"CHEK2","route":"/targets/chek2/","asOf":"2026-09-23","xrefs":[{"hgnc":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16627","ensembl":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000183765","uniprot":"https://www.uniprot.org/uniprotkb/O96017/entry","alphafold-db":"https://alphafold.ebi.ac.uk/entry/O96017","open-targets":"https://platform.opentargets.org/target/ENSG00000183765","civic":"https://civicdb.org/genes/11200/summary","oncokb":"https://www.oncokb.org/gene/CHEK2","cosmic":"https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=CHEK2","cbioportal":"https://www.cbioportal.org/results/mutations?cancer_study_list=msk_impact_2017&gene_list=CHEK2","depmap":"https://depmap.org/portal/gene/CHEK2?tab=overview","human-protein-atlas":"https://www.proteinatlas.org/ENSG00000183765-CHEK2","ncbi-gene":"https://www.ncbi.nlm.nih.gov/gene/11200","omim":"https://www.omim.org/entry/604373"}],"products":[],"trials":[],"pathways":[],"companies":[],"keyPapers":["paper-jensen-clonal-haematopoiesis-cfdna-interference-prostate-jama-oncol-2021","paper-tukachinsky-ctdna-3334-advanced-prostate-ccr-2021","paper-nicolosi-germline-variants-prostate-testing-guidelines-jama-oncol-2019","paper-isaacsson-velho-intraductal-germline-dna-repair-prostate-2018","paper-pritchard-inherited-dna-repair-metastatic-prostate-nejm-2016"],"hotspots":[],"openQuestions":[],"assays":[],"resistance":[],"licence":"CC BY-NC 4.0, attribution to OnCo (https://onco.cc); commercial use needs a licence"}