{"id":"cd73-adenosine","name":"CD73 / adenosine axis","symbol":"NT5E","route":"/targets/cd73-adenosine/","asOf":"2026-09-08","xrefs":[{"hgnc":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8021","ensembl":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000135318","uniprot":"https://www.uniprot.org/uniprotkb/P21589/entry","alphafold-db":"https://alphafold.ebi.ac.uk/entry/P21589","chembl":"https://www.ebi.ac.uk/chembl/explore/target/CHEMBL5957","open-targets":"https://platform.opentargets.org/target/ENSG00000135318","civic":"https://civicdb.org/genes/4907/summary","oncokb":"https://www.oncokb.org/gene/NT5E","cosmic":"https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=NT5E","cbioportal":"https://www.cbioportal.org/results/mutations?cancer_study_list=msk_impact_2017&gene_list=NT5E","depmap":"https://depmap.org/portal/gene/NT5E?tab=overview","human-protein-atlas":"https://www.proteinatlas.org/ENSG00000135318-NT5E","ncbi-gene":"https://www.ncbi.nlm.nih.gov/gene/4907","omim":"https://www.omim.org/entry/129190"}],"products":[{"id":"ak119","name":"AK119","status":"phase-2","modality":"monoclonal antibody","route":"/drugs/ak119/"},{"id":"mavrostobart","name":"Mavrostobart","status":"phase-2","modality":"monoclonal antibody","route":"/drugs/mavrostobart/"}],"trials":[{"id":"nct05846867","name":"A Phase Ib/II Clinical Study on AK112 Combined or Not Combined With AK119 in pMMR/MSS Colorectal Cancer","nct":"NCT05846867","phase":"1/2","status":"active"},{"id":"nct05431270","name":"Dose Escalation/Expansion Study of Mavrostobart (PT199), an Anti-CD73 mAb, Administered Alone and in Combination With a PD-1 Inhibitor or Chemotherapy","nct":"NCT05431270","phase":"1/2","status":"recruiting"},{"id":"nct05689853","name":"Study of AK119 Combined With AK112 in Patients With Advanced Solid Tumors","nct":"NCT05689853","phase":"1/2","status":"recruiting"}],"pathways":["nutrient-competition-tme"],"companies":["akeso","phanes-therapeutics"],"keyPapers":["paper-herbst-j-clin-oncol"],"hotspots":[],"openQuestions":[],"assays":[],"resistance":[],"licence":"CC BY-NC 4.0, attribution to OnCo (https://onco.cc); commercial use needs a licence"}