{"id":"cd30","name":"CD30","symbol":"TNFRSF8","route":"/targets/cd30/","asOf":"2026-09-07","xrefs":[{"hgnc":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11923","ensembl":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000120949","uniprot":"https://www.uniprot.org/uniprotkb/P28908/entry","alphafold-db":"https://alphafold.ebi.ac.uk/entry/P28908","chembl":"https://www.ebi.ac.uk/chembl/explore/target/CHEMBL2364161","open-targets":"https://platform.opentargets.org/target/ENSG00000120949","civic":"https://civicdb.org/genes/943/summary","oncokb":"https://www.oncokb.org/gene/TNFRSF8","cosmic":"https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=TNFRSF8","cbioportal":"https://www.cbioportal.org/results/mutations?cancer_study_list=msk_impact_2017&gene_list=TNFRSF8","depmap":"https://depmap.org/portal/gene/TNFRSF8?tab=overview","human-protein-atlas":"https://www.proteinatlas.org/ENSG00000120949-TNFRSF8","ncbi-gene":"https://www.ncbi.nlm.nih.gov/gene/943","omim":"https://www.omim.org/entry/153243"}],"products":[{"id":"eb-car30-nk","name":"EB-CAR30-NK","status":"phase-2","modality":"CAR-NK cell therapy","route":"/drugs/eb-car30-nk/"}],"trials":[{"id":"nct04404283","name":"Brentuximab Vedotin Plus Lenalidomide and Rituximab for the Treatment of Relapsed/Refractory DLBCL","nct":"NCT04404283","phase":"3","status":"active"},{"id":"echelon-1","name":"ECHELON-1","nct":"NCT01712490","phase":"3","status":"positive"},{"id":"radar-hodgkin","name":"RADAR","nct":"NCT04685616","phase":"3","status":"active"},{"id":"nct07598955","name":"Target-Selected CAR-NK Cells (CD30, CD5, or Mesothelin) for Relapsed/Refractory B2 Thymoma or Thymic Carcinoma","nct":"NCT07598955","phase":"1/2","status":"recruiting"}],"pathways":[],"companies":[],"keyPapers":["paper-echelon-3-brentuximab-lenalidomide-rituximab-dlbcl-jco-2025","paper-swog-s1826-nivolumab-avd-nejm-2024","paper-echelon-1-brentuximab-avd-nejm-2018"],"hotspots":[],"openQuestions":[],"assays":[],"resistance":[{"class":"pd1-hodgkin","mechanism":"Loss of MHC class II on the Reed-Sternberg cell","category":"immune-evasion"}],"licence":"CC BY-NC 4.0, attribution to OnCo (https://onco.cc); commercial use needs a licence"}