{"id":"cd28","name":"CD28","symbol":"CD28","route":"/targets/cd28/","asOf":"2026-09-22","xrefs":[{"hgnc":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1653","ensembl":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000178562","uniprot":"https://www.uniprot.org/uniprotkb/P10747/entry","alphafold-db":"https://alphafold.ebi.ac.uk/entry/P10747","chembl":"https://www.ebi.ac.uk/chembl/explore/target/CHEMBL5191","open-targets":"https://platform.opentargets.org/target/ENSG00000178562","civic":"https://civicdb.org/genes/940/summary","oncokb":"https://www.oncokb.org/gene/CD28","cosmic":"https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=CD28","cbioportal":"https://www.cbioportal.org/results/mutations?cancer_study_list=msk_impact_2017&gene_list=CD28","depmap":"https://depmap.org/portal/gene/CD28?tab=overview","human-protein-atlas":"https://www.proteinatlas.org/ENSG00000178562-CD28","ncbi-gene":"https://www.ncbi.nlm.nih.gov/gene/940","omim":"https://www.omim.org/entry/186760"}],"products":[{"id":"jnj-87189401","name":"JNJ-87189401","status":"phase-3","modality":"costimulatory bispecific antibody (PSMA x CD28, per the sponsor's pipeline page)","route":"/drugs/jnj-87189401/"}],"trials":[{"id":"mcrpc","name":"A Study of Pasritamig With or Without JNJ-87189401 Versus Placebo for Late Line Metastatic Castration-resistant Prostate Cancer (mCRPC)","nct":"NCT07164443","phase":"3","status":"recruiting"}],"pathways":[],"companies":["johnson-johnson"],"keyPapers":[],"hotspots":[],"openQuestions":[],"assays":[],"resistance":[],"licence":"CC BY-NC 4.0, attribution to OnCo (https://onco.cc); commercial use needs a licence"}