{"id":"apc","name":"APC","symbol":"APC","route":"/targets/apc/","asOf":"2026-09-23","xrefs":[{"hgnc":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:583","ensembl":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000134982","uniprot":"https://www.uniprot.org/uniprotkb/P25054/entry","alphafold-db":"https://alphafold.ebi.ac.uk/entry/P25054","open-targets":"https://platform.opentargets.org/target/ENSG00000134982","civic":"https://civicdb.org/genes/324/summary","oncokb":"https://www.oncokb.org/gene/APC","cosmic":"https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=APC","cbioportal":"https://www.cbioportal.org/results/mutations?cancer_study_list=msk_impact_2017&gene_list=APC","depmap":"https://depmap.org/portal/gene/APC?tab=overview","human-protein-atlas":"https://www.proteinatlas.org/ENSG00000134982-APC","ncbi-gene":"https://www.ncbi.nlm.nih.gov/gene/324","omim":"https://www.omim.org/entry/611731"}],"products":[],"trials":[],"pathways":[],"companies":[],"keyPapers":["paper-diaz-gay-colibactin-geographic-age-mutational-processes-nature-2025","paper-pandey-gallbladder-elf3-nat-commun-2020","paper-stopsack-mcspc-genomic-alterations-outcomes-ccr-2020","paper-lee-six-somatic-mutation-normal-colorectal-crypts-nature-2019","paper-yaeger-metastatic-colorectal-genomic-landscape-cancer-cell-2018","paper-grasso-immune-evasion-colorectal-cancer-discov-2018","paper-tauriello-tgfbeta-immune-evasion-colorectal-nature-2018","paper-robinson-integrative-clinical-genomics-advanced-prostate-cell-2015","paper-tcga-colorectal-comprehensive-characterization-nature-2012","paper-seshagiri-rspo-fusions-colon-nature-2012","paper-fearon-cell","paper-vogelstein-genetic-alterations-colorectal-tumor-development-nejm-1988"],"hotspots":[],"openQuestions":[],"assays":[],"resistance":[],"licence":"CC BY-NC 4.0, attribution to OnCo (https://onco.cc); commercial use needs a licence"}