{"id":"acvr1","name":"ACVR1 (ALK2)","symbol":"ACVR1","route":"/targets/acvr1/","asOf":"2026-09-22","xrefs":[{"hgnc":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:171","ensembl":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000115170","uniprot":"https://www.uniprot.org/uniprotkb/Q04771/entry","alphafold-db":"https://alphafold.ebi.ac.uk/entry/Q04771","chembl":"https://www.ebi.ac.uk/chembl/explore/target/CHEMBL5903","open-targets":"https://platform.opentargets.org/target/ENSG00000115170","civic":"https://civicdb.org/genes/90/summary","oncokb":"https://www.oncokb.org/gene/ACVR1","cosmic":"https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=ACVR1","cbioportal":"https://www.cbioportal.org/results/mutations?cancer_study_list=msk_impact_2017&gene_list=ACVR1","depmap":"https://depmap.org/portal/gene/ACVR1?tab=overview","human-protein-atlas":"https://www.proteinatlas.org/ENSG00000115170-ACVR1","ncbi-gene":"https://www.ncbi.nlm.nih.gov/gene/90","omim":"https://www.omim.org/entry/102576"}],"products":[{"id":"momelotinib","name":"Momelotinib","status":"approved","modality":"Small-molecule JAK1/JAK2/ACVR1 inhibitor","route":"/drugs/momelotinib/"},{"id":"pacritinib","name":"Pacritinib","status":"approved","modality":"Small-molecule JAK2/IRAK1/ACVR1 inhibitor","route":"/drugs/pacritinib/"}],"trials":[{"id":"momentum","name":"MOMENTUM","nct":"NCT04173494","phase":"3","status":"positive"},{"id":"nct07033598","name":"Pacritinib vs. Hydroxyurea in Advanced Proliferative Chronic Myelomonocytic Leukemia","nct":"NCT07033598","phase":"2","status":"recruiting"}],"pathways":[],"companies":["gsk","sobi"],"keyPapers":[],"hotspots":[],"openQuestions":[],"assays":[],"resistance":[],"licence":"CC BY-NC 4.0, attribution to OnCo (https://onco.cc); commercial use needs a licence"}