# Y-mAbs Therapeutics

Source: https://onco.cc/companies/y-mabs/  
OnCo record `y-mabs` (Company). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

MSK spin-out that commercialises naxitamab, the humanised anti-GD2 antibody for relapsed neuroblastoma, and develops pretargeted radioimmunotherapy.

## Summary

Y-mAbs Therapeutics, based in New York and listed as YMAB, is a Memorial Sloan Kettering spin-out that commercialises naxitamab, the humanised anti-GD2 antibody for relapsed neuroblastoma, and develops pretargeted radioimmunotherapy. Naxitamab, sold as Danyelza, received accelerated approval in November 2020; omburtamab, a B7-H3 antibody carrying iodine-131, was rejected by the FDA in 2022; and the SADA pretargeted radioimmunotherapy platform, with a GD2-SADA and lutetium-177 pairing, is in phase 1. OnCo links it to paediatric neuroblastoma, to GD2 as a target and to the bottleneck of rare and paediatric cancers without markets. Whether pretargeting can deliver radiation to paediatric tumours with less marrow toxicity than direct radioimmunotherapy is the open question. Naxitamab has its own page.

## Fields

- Kind: Company
- Last checked: 2026-09-07
- HQ: New York, NY
- Type: biotech
- Website: https://www.ymabs.com
- Ticker: YMAB

## Sources

- Official website: https://www.ymabs.com

## Connected records

- cancers: [High-risk neuroblastoma](https://onco.cc/cancers/neuroblastoma-high-risk/), [Neuroblastoma (paediatric)](https://onco.cc/cancers/neuroblastoma/)
- fronts: [Immunotherapy](https://onco.cc/fronts/immunotherapy/), [Radiopharmaceuticals & Theranostics](https://onco.cc/fronts/radiopharma/)
- targets: [GD2 (disialoganglioside)](https://onco.cc/targets/gd2/)
- drugs: [Naxitamab](https://onco.cc/drugs/naxitamab/)
- trials: [Naxitamab Study 201](https://onco.cc/trials/naxitamab-201/)
- bottlenecks: [Rare and paediatric cancers without markets](https://onco.cc/bottlenecks/b-rare-cancers/)
- roadmaps: [Paediatric oncology roadmap: cooperative-group cures → engineered immunity → drugs developed for children first](https://onco.cc/roadmaps/paediatric-oncology-roadmap/)

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