# Waseem Qasim

Source: https://onco.cc/people/waseem-qasim/  
OnCo record `waseem-qasim` (Person). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Delivered the first gene-edited off-the-shelf CAR-T cells to infants with leukaemia and the first base-edited CAR-T therapy.

## Summary

Waseem Qasim led the compassionate use and then trials of UCART19, TALEN-edited universal donor CAR T cells, in infants and children with refractory ALL, the first clinical use of gene-edited allogeneic CAR-T. In 2023 his team reported the first patient treated with base-edited CAR7 T cells for T-cell ALL, a disease where autologous CAR-T is impractical. He leads cell and gene therapy at Great Ormond Street.

## Fields

- Kind: Person
- Last checked: 2026-09-10
- Tags: cell-therapy; gene-editing; paediatric
- Role: Professor of Cell and Gene Therapy, UCL Great Ormond Street Institute of Child Health
- Specialisms: Gene-edited cell therapy; Allogeneic CAR T cells; Base editing; Paediatric leukaemia

## Sources

- PubMed: https://pubmed.ncbi.nlm.nih.gov/?term=Qasim%20W%5BAuthor%5D%20CAR%20T%20gene-edited

## Connected records

- cancers: [Acute lymphoblastic leukaemia](https://onco.cc/cancers/all-leukemia/)
- technologies: [Allogeneic (off-the-shelf) cell therapy](https://onco.cc/technologies/allogeneic-cell-therapy/), [CAR-T cell therapy](https://onco.cc/technologies/car-t/), [CRISPR functional genomics](https://onco.cc/technologies/crispr-screens/)
- targets: [CD19](https://onco.cc/targets/cd19/)
- institutions: [Great Ormond Street Hospital for Children](https://onco.cc/institutions/great-ormond-street/)
- key papers: [UCART19: the first gene-edited, donor-derived CAR-T cells in children and adults with relapsed B-cell ALL](https://onco.cc/key-papers/paper-ucart19-allogeneic-car-t-lancet-2020/)

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