# University of Chicago Medicine Comprehensive Cancer Center

Source: https://onco.cc/institutions/uchicago-cancer/  
OnCo record `uchicago-cancer` (Institution). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Where Charles Huggins proved hormones drive prostate cancer and Janet Rowley found the chromosome translocations behind leukaemia; strong in tumour immunology today.

## Summary

NCI-designated since 1973 and comprehensive since 2008, the University of Chicago has two foundational cancer discoveries to its name: Charles Huggins's demonstration that castration controls prostate cancer (Nobel Prize 1966), the origin of hormonal therapy, and Janet Rowley's identification of recurrent chromosomal translocations, including the 9;22 translocation that produces BCR-ABL. Today Thomas Gajewski's laboratory defined the T-cell-inflamed ('hot') tumour phenotype and the gut microbiome's influence on checkpoint response; Everett Vokes established chemoradiotherapy for head and neck cancer; Susan Cohn leads international neuroblastoma risk classification. The centre is building a dedicated cancer hospital on its Hyde Park campus.

## Fields

- Kind: Institution
- Last checked: 2026-09-09
- Also known as: UCCCC
- City: Chicago, IL, US
- Type: cancer-center
- NCI designation: comprehensive
- Website: https://cancer.uchicago.edu

## Sources

- UChicago Medicine Comprehensive Cancer Center: https://cancer.uchicago.edu
- Clinical trials: https://cancer.uchicago.edu/clinical-trials/

## Connected records

- cancers: [Chronic myeloid leukaemia (CML)](https://onco.cc/cancers/cml/), [Head and neck squamous cell carcinoma](https://onco.cc/cancers/head-and-neck/), [Neuroblastoma (paediatric)](https://onco.cc/cancers/neuroblastoma/), [Prostate cancer](https://onco.cc/cancers/prostate/)
- fronts: [Hormonal Therapy](https://onco.cc/fronts/hormonal/), [Immunotherapy](https://onco.cc/fronts/immunotherapy/)
- technologies: [Androgen deprivation & AR pathway inhibitors](https://onco.cc/technologies/androgen-deprivation/), [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/), [Microbiome modulation to unlock immunotherapy](https://onco.cc/technologies/microbiome-modulation-io/)
- targets: [Androgen receptor](https://onco.cc/targets/androgen-receptor/), [BCR::ABL1 (Philadelphia chromosome)](https://onco.cc/targets/bcr-abl/)
- terms: [Hot vs cold tumours](https://onco.cc/terms/cold-vs-hot/)
- people: [Daniel K. Ludwig](https://onco.cc/people/daniel-ludwig/), [Everett E. Vokes](https://onco.cc/people/everett-vokes/), [Hedy L. Kindler](https://onco.cc/people/hedy-kindler/), [Kunle Odunsi](https://onco.cc/people/kunle-odunsi/), [Ralph Weichselbaum](https://onco.cc/people/ralph-weichselbaum/), [Susan L. Cohn](https://onco.cc/people/susan-cohn/), [Thomas F. Gajewski](https://onco.cc/people/thomas-gajewski/)
- institutions: [Ludwig Cancer Research](https://onco.cc/institutions/ludwig-cancer-research/), [National Cancer Institute (NIH)](https://onco.cc/institutions/nci/), [University College Hospital, Ibadan](https://onco.cc/institutions/uch-ibadan/)

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