# 7+3 induction chemotherapy

Source: https://onco.cc/terms/seven-plus-three/  
OnCo record `seven-plus-three` (Term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

The classic first treatment for acute myeloid leukaemia, unchanged since 1973: seven days of continuous cytarabine plus three days of an anthracycline, given in hospital. Fit patients still get it, now with a targeted drug added according to their leukaemia's genetics.

## Summary

7+3 achieves complete remission in 60-80% of younger adults and is followed by consolidation (high-dose cytarabine) or allogeneic transplant depending on ELN risk. Additions by genotype: midostaurin or quizartinib for FLT3 mutations, gemtuzumab ozogamicin for favourable-risk CD33-positive disease, CPX-351 (liposomal 7+3) for secondary AML. Patients unfit for intensive chemotherapy receive venetoclax plus azacitidine, which is eroding the boundary between 'intensive' and 'non-intensive' approaches. Induction mortality is 5-10% and the main risks are infection and bleeding during weeks of aplasia.

## Fields

- Kind: Term
- Last checked: 2026-09-09
- Also known as: 7+3; 7 + 3; cytarabine-anthracycline; cytarabine plus daunorubicin; intensive chemotherapy; intensive induction; non-intensive; non-intensive therapy; less intensive; CPX-351; Vyxeos; HiDAC; high-dose cytarabine; FLAG-IDA

## Sources

- Wikipedia: https://en.wikipedia.org/wiki/Acute_myeloid_leukemia#Treatment
- Wikipedia: https://en.wikipedia.org/wiki/Acute_myeloid_leukemia#Treatment

## Connected records

- terms: [Allogeneic stem cell transplant (allo-SCT)](https://onco.cc/terms/allogeneic-transplant/), [Anthracyclines (doxorubicin, epirubicin)](https://onco.cc/terms/anthracycline/), [Hypomethylating agents (azacitidine, decitabine)](https://onco.cc/terms/hma/), [Induction therapy](https://onco.cc/terms/induction-therapy/)
- cancers: [Acute myeloid leukaemia](https://onco.cc/cancers/aml/), [FLT3-mutated acute myeloid leukaemia](https://onco.cc/cancers/aml-flt3/)
- fronts: [Chemotherapy](https://onco.cc/fronts/chemotherapy/)
- drugs: [Azacitidine](https://onco.cc/drugs/azacitidine/), [Gilteritinib](https://onco.cc/drugs/gilteritinib/), [Midostaurin](https://onco.cc/drugs/midostaurin/), [Venetoclax](https://onco.cc/drugs/venetoclax/)

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