# Scott J. Antonia

Source: https://onco.cc/people/scott-antonia/  
OnCo record `scott-antonia` (Person). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Led PACIFIC, which made a year of durvalumab after chemoradiation the standard for stage III lung cancer.

## Summary

Scott Antonia was principal investigator of PACIFIC, the trial showing consolidation durvalumab after chemoradiotherapy improves progression-free and overall survival in unresectable stage III NSCLC, the first curative-intent immunotherapy result in lung cancer. He also led early nivolumab work in small-cell lung cancer (CheckMate 032). He now directs immunotherapy and cell therapy programmes at Duke.

## Fields

- Kind: Person
- Last checked: 2026-09-10
- Tags: lung; immunotherapy; stage-iii
- Role: Director, Center for Cancer Immunotherapy, Duke Cancer Institute
- Specialisms: Lung cancer immunotherapy; Stage III NSCLC; Tumour immunology; Cell therapy

## Sources

- PubMed: https://pubmed.ncbi.nlm.nih.gov/?term=Antonia%20SJ%5BAuthor%5D%20durvalumab%20PACIFIC

## Connected records

- cancers: [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/), [Small-cell lung cancer](https://onco.cc/cancers/sclc/), [Unresectable stage III non-small-cell lung cancer](https://onco.cc/cancers/stage-iii-unresectable-nsclc/)
- technologies: [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/)
- targets: [PD-L1](https://onco.cc/targets/pdl1/)
- drugs: [Durvalumab](https://onco.cc/drugs/durvalumab/), [Nivolumab](https://onco.cc/drugs/nivolumab/)
- institutions: [Duke Cancer Institute](https://onco.cc/institutions/duke-cancer-institute/)
- trials: [PACIFIC](https://onco.cc/trials/pacific/)
- key papers: [Five-year survival outcomes from the PACIFIC trial: durvalumab after chemoradiotherapy in stage III non-small-cell lung cancer](https://onco.cc/key-papers/paper-spigel-pacific-five-year-survival-jco-2022/), [PACIFIC: a year of durvalumab after chemoradiotherapy for stage III lung cancer](https://onco.cc/key-papers/paper-pacific-nejm-2017/)

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