# Science

Source: https://onco.cc/journals/science/  
OnCo record `science` (Journal). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Science is the AAAS flagship and Nature's main rival. It is home to landmark cancer papers on mismatch repair and immunotherapy, cancer genome sequencing, liquid biopsy and the microbiome.

## Summary

Science is a weekly multidisciplinary journal. Cancer landmarks include the Vogelstein group's tumour sequencing and CancerSEEK papers, the mismatch-repair deficiency and PD-1 tumour-agnostic work, gut microbiome and immunotherapy response studies, and the ecDNA and chromothripsis discoveries. Subscription with free access after 12 months and a green open-access policy; Science Translational Medicine and Science Immunology are sister titles.

## Fields

- Kind: Journal
- Last checked: 2026-09-09
- Also known as: Science (AAAS)
- Publisher: American Association for the Advancement of Science
- Scope: general science
- Access: subscription

## Sources

- Wikipedia: https://en.wikipedia.org/wiki/Science_(journal)
- Science cancer collection: https://www.science.org/topic/category/cancer

## Connected records

- key papers: [Accurate proteome-wide missense variant effect prediction with AlphaMissense](https://onco.cc/key-papers/paper-cheng-science/), [Adrenergic nerves activate an angio-metabolic switch in prostate cancer](https://onco.cc/key-papers/paper-zahalka-science/), [Bischoff 1996: the adenovirus that was said to replicate only where p53 was lost](https://onco.cc/key-papers/paper-bischoff-onyx-015-science-1996/), [Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions](https://onco.cc/key-papers/paper-tomasetti-science/), [Cancer genome landscapes: about 140 driver genes, and each tumour needs only a handful](https://onco.cc/key-papers/paper-vogelstein-cancer-genome-landscapes-science-2013/), [Clonal hematopoiesis in human aging and disease](https://onco.cc/key-papers/paper-jaiswal-science/), [Coffey 1998: reovirus grows in cells with an activated Ras pathway, which describes a great many cancers](https://onco.cc/key-papers/paper-coffey-reovirus-ras-science-1998/), [Core signaling pathways in human pancreatic cancers revealed by global genomic analyses](https://onco.cc/key-papers/paper-jones-pancreatic-core-pathways-science-2008/), [DETECT-A: a blood test plus PET-CT found treatable cancers in 10,000 women with no symptoms](https://onco.cc/key-papers/paper-detect-a-science-2020/), [Detection and localization of surgically resectable cancers with a multi-analyte blood test](https://onco.cc/key-papers/paper-cohen-cancerseek-multi-analyte-blood-test-science-2018/), [Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response](https://onco.cc/key-papers/paper-spencer-science/), [Early detection of cancer](https://onco.cc/key-papers/paper-crosby-science/), [EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy](https://onco.cc/key-papers/paper-paez-egfr-mutations-gefitinib-science-2004/), [Epigenetic plasticity and the hallmarks of cancer](https://onco.cc/key-papers/paper-flavahan-science/), [Fecal microbiota transplant overcomes resistance to anti-PD-1 therapy in melanoma patients](https://onco.cc/key-papers/paper-davar-science/), [Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients](https://onco.cc/key-papers/paper-baruch-science/), [Frequent mutations of the chromatin remodelling gene ARID1A in ovarian clear cell carcinoma](https://onco.cc/key-papers/paper-jones-arid1a-clear-cell-science-2010/), [Gain-of-function mutations of c-kit in human gastrointestinal stromal tumours](https://onco.cc/key-papers/paper-hirota-kit-gist-science-1998/), [Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability](https://onco.cc/key-papers/paper-markowitz-tgfbr2-inactivation-msi-colon-science-1995/), [Inhibition of hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer](https://onco.cc/key-papers/paper-olive-hedgehog-stroma-gemcitabine-delivery-science-2009/), [Kinase-impaired BTK mutations are susceptible to clinical-stage BTK and IKZF1/3 degrader NX-2127](https://onco.cc/key-papers/paper-montoya-science/), [Le 2017: mismatch-repair deficiency predicts response to PD-1 blockade across twelve tumour types, leading to the first tissue-agnostic drug approval](https://onco.cc/key-papers/paper-le-mmr-deficiency-science-2017/), [Leach, Krummel and Allison: releasing the CTLA-4 brake makes mice reject tumours](https://onco.cc/key-papers/paper-leach-allison-ctla4-blockade-science-1996/), [Martincorena: normal sun-exposed skin is a patchwork of cancer-mutation clones](https://onco.cc/key-papers/paper-martincorena-somatic-mutations-normal-skin-science-2015/), [Martuza 1991: the first genetically engineered virus built to treat a cancer](https://onco.cc/key-papers/paper-martuza-engineered-hsv-glioma-science-1991/), [MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling](https://onco.cc/key-papers/paper-engelman-met-amplification-gefitinib-resistance-science-2007/), [Mutational signatures associated with tobacco smoking in human cancer](https://onco.cc/key-papers/paper-alexandrov-tobacco-smoking-mutational-signatures-science-2016/), [Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice](https://onco.cc/key-papers/paper-albrengues-science/), [Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy](https://onco.cc/key-papers/paper-jain-science/), [On the origin of cancer cells](https://onco.cc/key-papers/paper-warburg-science/), [Pan-tumor genomic biomarkers for PD-1 checkpoint blockade-based immunotherapy](https://onco.cc/key-papers/paper-cristescu-science/), [PARP inhibitors: Synthetic lethality in the clinic](https://onco.cc/key-papers/paper-lord-science/), [PDGFRA activating mutations in gastrointestinal stromal tumours](https://onco.cc/key-papers/paper-heinrich-pdgfra-gist-science-2003/), [Physical traits of cancer](https://onco.cc/key-papers/paper-nia-science/), [Rb1 and Trp53 cooperate to suppress prostate cancer lineage plasticity, metastasis and antiandrogen resistance](https://onco.cc/key-papers/paper-ku-rb1-trp53-lineage-plasticity-science-2017/), [Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer](https://onco.cc/key-papers/paper-tomlins-tmprss2-ets-fusion-science-2005/), [Scalable emulation of protein equilibrium ensembles with generative deep learning](https://onco.cc/key-papers/paper-lewis-science/), [Simulating 500 million years of evolution with a language model](https://onco.cc/key-papers/paper-hayes-science/), [Somatic mutant clones colonize the human esophagus with age](https://onco.cc/key-papers/paper-martincorena-science/), [SOX2 promotes lineage plasticity and antiandrogen resistance in TP53- and RB1-deficient prostate cancer](https://onco.cc/key-papers/paper-mu-sox2-lineage-plasticity-science-2017/), [The clonal evolution of tumor cell populations](https://onco.cc/key-papers/paper-nowell-science/), [Tumor development after 3-methylcholanthrene in immunologically deficient athymic-nude mice](https://onco.cc/key-papers/paper-stutman-science/), [Understanding the Warburg effect: the metabolic requirements of cell proliferation](https://onco.cc/key-papers/paper-vander-heiden-science/)
- people: [Benjamin Kile](https://onco.cc/people/benjamin-kile/), [Erin K. O'Shea](https://onco.cc/people/erin-oshea/), [Fernando Peláez](https://onco.cc/people/fernando-pelaez/), [Yasmine Belkaid](https://onco.cc/people/yasmine-belkaid/)

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