# Raloxifene

Source: https://onco.cc/drugs/raloxifene/  
OnCo record `raloxifene` (Treatment). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Raloxifene (Evista) is an osteoporosis tablet that also lowers the chance of developing invasive breast cancer in postmenopausal women at higher risk, with fewer womb-cancer problems than tamoxifen.

## Summary

Raloxifene was approved in December 1997 for treatment and prevention of postmenopausal osteoporosis and in September 2007 for reduction in the risk of invasive breast cancer in postmenopausal women with osteoporosis or at high risk of breast cancer, on the MORE, CORE and RUTH trials and the head-to-head STAR trial (NSABP P-2), in which raloxifene was about as effective as tamoxifen against invasive breast cancer with fewer uterine cancers and thromboembolic events but less protection against non-invasive disease. It does not treat breast cancer or reduce recurrence. Venous thromboembolism and fatal stroke in women with coronary disease carry a boxed warning.

## Fields

- Kind: Treatment
- Status: approved
- Last checked: 2026-09-10
- Tags: nci-list; prevention
- Brand: Evista
- Modality: Selective oestrogen receptor modulator (benzothiophene)
- Mechanism: Oestrogen receptor agonist in bone and antagonist in breast and uterus; lowers the incidence of ER-positive invasive breast cancer.
- Approvals: US 1997: Treatment and prevention of postmenopausal osteoporosis; US 2007: Reduction in risk of invasive breast cancer in postmenopausal women with osteoporosis or at high risk

## Sources

- Wikipedia: https://en.wikipedia.org/wiki/Raloxifene
- US label (DailyMed): https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=raloxifene
- NCI drug page: https://www.cancer.gov/about-cancer/treatment/drugs/raloxifenehydrochloride

## Connected records

- drugs: [Tamoxifen](https://onco.cc/drugs/tamoxifen/)
- cancers: [HR-positive / HER2-negative breast cancer](https://onco.cc/cancers/breast-hr-positive/)
- technologies: [Chemoprevention & risk-reducing surgery](https://onco.cc/technologies/chemoprevention/), [Endocrine therapy (SERMs, AIs, SERDs)](https://onco.cc/technologies/endocrine-therapy/)
- targets: [Estrogen receptor (ERα)](https://onco.cc/targets/estrogen-receptor/)
- companies: [Eli Lilly (incl. Loxo)](https://onco.cc/companies/eli-lilly/)
- trials: [Bioequivalence ANDA SNP Clinical Study - Raloxifene and Single Nucleotide Polymorphisms](https://onco.cc/trials/nct06062810/)
- terms: [Chemoprevention (tamoxifen, anastrozole, raloxifene) and ER-negative breast cancer](https://onco.cc/terms/chemoprevention-and-er-negative-breast-cancer/)

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