# Raajit K. Rampal

Source: https://onco.cc/people/raajit-rampal/  
OnCo record `raajit-rampal` (Person). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

New York haematologist who led MANIFEST-2, the trial testing whether adding the BET inhibitor pelabresib to ruxolitinib helps people with myelofibrosis more than ruxolitinib alone.

## Summary

Raajit Rampal directs the myeloproliferative neoplasms programme at Memorial Sloan Kettering Cancer Center. He was the global lead investigator and first author of the primary report of MANIFEST-2, the phase 3 trial of pelabresib plus ruxolitinib against placebo plus ruxolitinib in JAK inhibitor-naive myelofibrosis, which met its spleen-volume primary endpoint. His research covers the genetics of progression from chronic myeloproliferative neoplasms to acute leukaemia.

## Fields

- Kind: Person
- Last checked: 2026-09-18
- Tags: mpn; trialist
- Role: Haematologist, Memorial Sloan Kettering Cancer Center
- Specialisms: Myelofibrosis; Myeloproliferative neoplasms; Combination therapy trials

## Connected records

- cancers: [Myeloproliferative neoplasms (PV, ET, myelofibrosis)](https://onco.cc/cancers/myeloproliferative-neoplasms/), [Primary myelofibrosis](https://onco.cc/cancers/primary-myelofibrosis/)
- institutions: [Memorial Sloan Kettering Cancer Center](https://onco.cc/institutions/mskcc/)
- trials: [MANIFEST-2](https://onco.cc/trials/manifest-2/)
- key papers: [Integrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis](https://onco.cc/key-papers/paper-raajit-rampal-blood-2014/), [JAK-STAT pathway activation in malignant and nonmalignant cells contributes to MPN pathogenesis and therapeutic response](https://onco.cc/key-papers/paper-raajit-rampal-cancer-discov-2015/), [Single-cell mutation analysis of clonal evolution in myeloid malignancies](https://onco.cc/key-papers/paper-raajit-rampal-nature-2020/)

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