# Study to Evaluate Adverse Events, Optimal Dose, and Change in Disease Activity, With Livmoniplimab in Combination With Budigalimab Plus Chemotherapy Versus IV Infused Pembrolizumab Plus Chemotherapy in Adult Participants With Untreated Metastatic Non-Squamous Non-Small Cell Lung Cancer (NSCLC)

Source: https://onco.cc/trials/nsclc-2/  
OnCo record `nsclc-2` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2/3 trial testing Budigalimab in non-small-cell lung cancer, now recruiting.

## Summary

Study to Evaluate Adverse Events, Optimal Dose, and Change in Disease Activity, With Livmoniplimab in Combination With Budigalimab Plus Chemotherapy Versus IV Infused Pembrolizumab Plus Chemotherapy in Adult Participants With Untreated Metastatic Non-Squamous Non-Small Cell Lung Cancer (NSCLC) is a phase 2/3 interventional study registered as NCT06236438, led by AbbVie, and recruiting on the registry. Official title: A Randomised, Phase 2/3 Study to Evaluate the Optimal Dose, Safety, and Efficacy of Livmoniplimab in Combination With Budigalimab Plus Chemotherapy Versus Pembrolizumab Plus Chemotherapy in Untreated Metastatic Non-Squamous Non-Small Cell Lung Cancer (NSCLC). Planned enrolment is 840 participants (estimated). The study started in 2024-04-10 and primary completion is expected in 2031-10. No results have been posted on ClinicalTrials.gov.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-11
- Also known as: LIVIGNO-4
- Tags: ctgov-ingest
- Registry id: NCT06236438
- Phase: 2/3
- Setting: A Randomized, Phase 2/3 Study to Evaluate the Optimal Dose, Safety, and Efficacy of Livmoniplimab in Combination With Budigalimab Plus Chemotherapy Versus Pembrolizumab Plus Chemotherapy in Untreated Metastatic Non-Squamous Non-Small Cell Lung Cancer (NSCLC)
- Sponsor: AbbVie
- Enrolled: 840

## Sources

- ClinicalTrials.gov NCT06236438: https://clinicaltrials.gov/study/NCT06236438

## Connected records

- cancers: [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)
- drugs: [Budigalimab](https://onco.cc/drugs/budigalimab/), [Livmoniplimab](https://onco.cc/drugs/livmoniplimab/)
- companies: [AbbVie (incl. ImmunoGen, Capstan)](https://onco.cc/companies/abbvie/)

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JSON: https://onco.cc/api/v1/entities/nsclc-2.json