# A Study of ASP2138 Together With Chemotherapy and Pembrolizumab in Adults With Gastric Cancer

Source: https://onco.cc/trials/nct07673887/  
OnCo record `nct07673887` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial testing ASP2138 in gastric & gastro-oesophageal junction cancer, now recruiting.

## Summary

A Study of ASP2138 Together With Chemotherapy and Pembrolizumab in Adults With Gastric Cancer is a phase 3 interventional study registered as NCT07673887, led by Astellas Pharma Global Development, and recruiting on the registry. Official title: A Phase 3, Global, Multi-centre, Double-blind, Randomised Study of ASP2138 Plus Chemotherapy (CAPOX or mFOLFOX6) With Pembrolizumab vs Placebo Plus Chemotherapy With or Without Pembrolizumab in First-line Treatment of Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma in Participants Whose Tumours Are HER2-negative and Claudin (CLDN) 18.2-positive. Planned enrolment is 570 participants (estimated). The study started in 2026-06-30 and primary completion is expected in 2031-02-28. No results have been posted on ClinicalTrials.gov.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-11
- Tags: ctgov-ingest
- Registry id: NCT07673887
- Phase: 3
- Setting: A Phase 3, Global, Multi-center, Double-blind, Randomized Study of ASP2138 Plus Chemotherapy (CAPOX or mFOLFOX6) With Pembrolizumab vs Placebo Plus Chemotherapy With or Without Pembrolizumab in First-line Treatment of Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma in Participants Whose Tumors Are HER2-negative and Claudin (CLDN) 18.2-positive
- Sponsor: Astellas Pharma Global Development
- Enrolled: 570

## Sources

- ClinicalTrials.gov NCT07673887: https://clinicaltrials.gov/study/NCT07673887

## Connected records

- cancers: [Gastric & gastro-oesophageal junction cancer](https://onco.cc/cancers/gastric/)
- drugs: [ASP2138](https://onco.cc/drugs/asp2138/)
- companies: [Astellas](https://onco.cc/companies/astellas/)

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