# A Study to Evaluate the Efficacy and Safety of IBI310 and Sintilimab Combination Therapy in Patients With Hepatocellular Carcinoma as First-line Treatment

Source: https://onco.cc/trials/nct07490262/  
OnCo record `nct07490262` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2/3 trial testing IBI310 in hepatocellular carcinoma, now recruiting.

## Summary

A Study to Evaluate the Efficacy and Safety of IBI310 and Sintilimab Combination Therapy in Patients With Hepatocellular Carcinoma as First-line Treatment is a phase 2/3 interventional study registered as NCT07490262, led by Innovent Biopharmaceutical Technology (Hangzhou), and recruiting on the registry. Official title: A Randomised, Open-label, Multicenter Study to Evaluate the Efficacy and Safety of IBI310 and Sintilimab Combination Therapy as First-line Treatment in Previously Untreated Patients With Unresectable or Metastatic Hepatocellular Carcinoma. Planned enrolment is 680 participants (estimated). The study started in 2026-03-27 and primary completion is expected in 2027-12-31. No results have been posted on ClinicalTrials.gov.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-11
- Tags: ctgov-ingest
- Registry id: NCT07490262
- Phase: 2/3
- Setting: A Randomized, Open-label, Multicenter Study to Evaluate the Efficacy and Safety of IBI310 and Sintilimab Combination Therapy as First-line Treatment in Previously Untreated Patients With Unresectable or Metastatic Hepatocellular Carcinoma
- Sponsor: Innovent Biopharmaceutical Technology (Hangzhou)
- Enrolled: 680

## Sources

- ClinicalTrials.gov NCT07490262: https://clinicaltrials.gov/study/NCT07490262

## Connected records

- cancers: [Advanced hepatocellular carcinoma (BCLC C)](https://onco.cc/cancers/hcc-advanced/), [Hepatocellular carcinoma](https://onco.cc/cancers/hcc/)
- drugs: [IBI310](https://onco.cc/drugs/ibi310/)
- companies: [Innovent Biologics](https://onco.cc/companies/innovent/)

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JSON: https://onco.cc/api/v1/entities/nct07490262.json