# Luveltamab tazevibulin

Source: https://onco.cc/drugs/luveltamab-tazevibulin/  
OnCo record `luveltamab-tazevibulin` (Treatment). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A folate-receptor ADC designed to work across low and high receptor levels, in a pivotal ovarian cancer trial.

## Summary

Sutro Biopharma's site-specifically conjugated FRα ADC. Phase 1 showed responses in FRα-low as well as FRα-high tumours; the phase 2/3 REFRαME-O1 trial in platinum-resistant ovarian cancer (any FRα expression >25%) is ongoing, with an interim analysis expected in 2026. Neutropenia and arthralgia are characteristic.

## Fields

- Kind: Treatment
- Status: phase-3
- Last checked: 2026-09-07
- Code: STRO-002
- Modality: ADC
- Mechanism: Anti-FRα antibody with a hemiasterlin microtubule inhibitor conjugated at defined non-natural amino acids.
- Payload: SC209 (hemiasterlin, tubulin inhibitor), DAR ~4
- Linker: Cleavable, site-specific (Sutro XpressCF)

## Sources

- REFRαME-O1: https://clinicaltrials.gov/study/NCT05870748

## Connected records

- cancers: [Advanced or recurrent endometrial cancer](https://onco.cc/cancers/advanced-recurrent-endometrial-cancer/), [Endometrial cancer](https://onco.cc/cancers/endometrial/), [Ovarian cancer](https://onco.cc/cancers/ovarian/), [Platinum-resistant ovarian cancer](https://onco.cc/cancers/platinum-resistant-ovarian-cancer/)
- technologies: [Antibody-drug conjugate (ADC)](https://onco.cc/technologies/adc/), [Site-specific conjugation & linker chemistry](https://onco.cc/technologies/site-specific-conjugation/)
- targets: [Folate receptor alpha](https://onco.cc/targets/folr1/)
- companies: [Sutro Biopharma](https://onco.cc/companies/sutro-biopharma/)
- trials: [REFRaME-O1: A Study to Investigate the Efficacy and Safety of Luveltamab Tazevibulin Versus Investigator's Choice (IC) Chemotherapy in Women With Ovarian Cancer (Including Fallopian Tube or Primary Peritoneal Cancers) Expressing FOLR1](https://onco.cc/trials/nct05870748/)
- ideas: [Sequence folate-receptor ADCs by payload class](https://onco.cc/ideas/idea-fra-adc-sequencing-ovarian/)

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