# Barbara Ann Karmanos Cancer Institute

Source: https://onco.cc/institutions/karmanos/  
OnCo record `karmanos` (Institution). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Detroit's NCI comprehensive cancer centre, where the MCF-7 breast cancer cell line was derived in 1973, now part of McLaren Health Care.

## Summary

Karmanos descends from the Michigan Cancer Foundation, where in 1973 Herbert Soule derived MCF-7, the oestrogen-receptor-positive breast cancer cell line that became the most studied cancer cell model in the world. NCI-designated since 1978, it is Wayne State University's cancer centre and, since 2014, part of McLaren Health Care, giving it a statewide network of cancer sites across Michigan. It has long run one of the larger academic phase 1 programmes and studies cancer in Detroit's predominantly Black population. Karmanos also operates the Detroit metropolitan SEER registry.

## Fields

- Kind: Institution
- Last checked: 2026-09-09
- Also known as: Karmanos; Michigan Cancer Foundation
- City: Detroit, MI, US
- Type: cancer-center
- NCI designation: comprehensive
- Website: https://www.karmanos.org

## Sources

- Wikipedia: https://en.wikipedia.org/wiki/Karmanos_Cancer_Institute
- Karmanos Cancer Institute: https://www.karmanos.org

## Connected records

- cancers: [HR-positive / HER2-negative breast cancer](https://onco.cc/cancers/breast-hr-positive/)
- technologies: [Endocrine therapy (SERMs, AIs, SERDs)](https://onco.cc/technologies/endocrine-therapy/)
- targets: [Estrogen receptor (ERα)](https://onco.cc/targets/estrogen-receptor/)
- terms: [Real-world evidence](https://onco.cc/terms/real-world-evidence/)
- people: [Boris C. Pasche](https://onco.cc/people/boris-pasche/)
- bottlenecks: [Lab models that fail to predict what happens in patients](https://onco.cc/bottlenecks/b-preclinical-models/), [Trials do not represent the people who get cancer](https://onco.cc/bottlenecks/b-trial-diversity/)
- institutions: [National Cancer Institute (NIH)](https://onco.cc/institutions/nci/)
- collections: [NCI-Designated Cancer Centers](https://onco.cc/collections/nci-cancer-centers/)

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JSON: https://onco.cc/api/v1/entities/karmanos.json