# Jean-Charles Soria

Source: https://onco.cc/people/jean-charles-soria/  
OnCo record `jean-charles-soria` (Person). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Ran the phase 1 unit that pioneered many targeted therapies, and led the FLAURA trial that made osimertinib first-line.

## Summary

Jean-Charles Soria is Professor of Medicine at Paris-Saclay and a former Director General of Gustave Roussy. His specialisms are early drug development, EGFR-mutant lung cancer and phase 1 trials. He built the DITEP early-phase unit at Gustave Roussy, which pioneered many targeted therapies, and led FLAURA, the New England Journal of Medicine trial of osimertinib in untreated EGFR-mutated advanced non-small-cell lung cancer that made osimertinib the first-line standard. He later served as Director General and as an industry research and development leader before returning to academic medicine. His publications are listed on PubMed.

## Fields

- Kind: Person
- Last checked: 2026-09-08
- Role: Professor of Medicine, Paris-Saclay; former Director General, Gustave Roussy
- Specialisms: Early drug development; EGFR-mutant lung cancer; Phase 1 trials

## Sources

- PubMed: https://pubmed.ncbi.nlm.nih.gov/?term=Soria%20JC%5BAuthor%5D%20osimertinib

## Connected records

- cancers: [EGFR-mutated non-small-cell lung cancer](https://onco.cc/cancers/egfr-mutant-nsclc/), [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)
- targets: [EGFR](https://onco.cc/targets/egfr/)
- drugs: [Osimertinib](https://onco.cc/drugs/osimertinib/)
- institutions: [Gustave Roussy](https://onco.cc/institutions/gustave-roussy/)
- key papers: [First-line ceritinib versus platinum-based chemotherapy in advanced ALK-rearranged non-small-cell lung cancer (ASCEND-4): a randomised, open-label, phase 3 study](https://onco.cc/key-papers/paper-ascend-4-lancet-2017/), [FLAURA: osimertinib as first treatment for EGFR-mutated lung cancer](https://onco.cc/key-papers/paper-flaura-nejm-2018/)
- trials: [ASCEND-4](https://onco.cc/trials/nct01828099/), [FLAURA](https://onco.cc/trials/flaura/)

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