# Ivospemin

Source: https://onco.cc/drugs/ivospemin/  
OnCo record `ivospemin` (Treatment). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Ivospemin is an experimental small-molecule drug from Panbela Therapeutics in phase 3 trials for pancreatic ductal adenocarcinoma, with its target not yet stated publicly.

## Summary

Ivospemin (SBP-101) is a small-molecule drug developed by Panbela Therapeutics. The sponsor describes its target as polyamine metabolism, which OnCo does not yet have a target page for. The sponsor states: A small-molecule polyamine metabolic inhibitor administered by subcutaneous injection. ClinicalTrials.gov describes the intervention as: small molecule polyamine metabolic inhibitor for subcutaneous injection. It is the investigational product in 1 recruiting or active industry-led phase 2 and phase 3 interventional cancer trial, including the phase 3 study NCT05254171 (Study of Nab-Paclitaxel and Gemcitabine With or Without SBP-101 in Pancreatic Cancer), in pancreatic ductal adenocarcinoma. The largest, NCT05254171, plans to enrol 600 participants with primary completion was scheduled for 2026-08-29 on the registry. Status reflects the highest phase registered on ClinicalTrials.gov; no efficacy results are recorded here.

## Fields

- Kind: Treatment
- Status: phase-3
- Last checked: 2026-09-11
- Tags: pipeline; ctgov-ingest
- Code: SBP-101
- Modality: small molecule
- Mechanism: A small-molecule polyamine metabolic inhibitor administered by subcutaneous injection.

## Sources

- ClinicalTrials.gov: trials of Ivospemin: https://clinicaltrials.gov/search?intr=Ivospemin

## Connected records

- cancers: [Pancreatic ductal adenocarcinoma](https://onco.cc/cancers/pancreatic/)
- companies: [Panbela Therapeutics](https://onco.cc/companies/panbela-therapeutics/)
- trials: [Study of Nab-Paclitaxel and Gemcitabine With or Without SBP-101 in Pancreatic Cancer](https://onco.cc/trials/nct05254171/)

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JSON: https://onco.cc/api/v1/entities/ivospemin.json