# Isabelle Ray-Coquard

Source: https://onco.cc/people/isabelle-ray-coquard/  
OnCo record `isabelle-ray-coquard` (Person). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Led PAOLA-1, which showed olaparib plus bevacizumab helps women with HRD-positive ovarian cancer beyond BRCA carriers.

## Summary

Isabelle Ray-Coquard was principal investigator of PAOLA-1, the ENGOT/GINECO trial showing maintenance olaparib added to bevacizumab improves progression-free and overall survival in first-line advanced ovarian cancer with homologous recombination deficiency, which made HRD testing a standard part of ovarian cancer care. She leads the French GINECO group and international networks for rare gynaecological cancers.

## Fields

- Kind: Person
- Last checked: 2026-09-10
- Tags: ovarian; parp; hrd
- Role: Professor of Medical Oncology, Centre Léon Bérard and Université Claude Bernard Lyon 1; President, GINECO
- Specialisms: Ovarian cancer; Rare gynaecological tumours; PARP inhibitor combinations; Sarcoma

## Sources

- PubMed: https://pubmed.ncbi.nlm.nih.gov/?term=Ray-Coquard%20I%5BAuthor%5D%20ovarian%20PAOLA

## Connected records

- cancers: [Ovarian cancer](https://onco.cc/cancers/ovarian/)
- technologies: [Anti-angiogenic therapy](https://onco.cc/technologies/antiangiogenic/), [HRD & BRCA testing](https://onco.cc/technologies/hrd-testing/), [PARP inhibitors](https://onco.cc/technologies/parp-inhibitor/)
- targets: [BRCA1 / BRCA2 (HRD)](https://onco.cc/targets/brca/), [PARP](https://onco.cc/targets/parp/), [VEGF / VEGFR](https://onco.cc/targets/vegf/)
- drugs: [Olaparib](https://onco.cc/drugs/olaparib/)
- companies: [ARCAGY-GINECO](https://onco.cc/companies/arcagy-gineco/)
- institutions: [Centre Léon Bérard](https://onco.cc/institutions/centre-leon-berard/)
- trials: [PAOLA-1 / ENGOT-ov25](https://onco.cc/trials/paola-1/)
- key papers: [PAOLA-1: olaparib added to bevacizumab maintenance in newly diagnosed ovarian cancer, with benefit confined to HRD-positive tumours](https://onco.cc/key-papers/paper-paola-1-nejm-2019/)

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