# Fund regulator-ready evidence dossiers for the 20 best-supported off-patent drugs

Source: https://onco.cc/ideas/idea-reg-regulator-ready-repurposing-dossiers/  
OnCo record `idea-reg-regulator-ready-repurposing-dossiers` (Idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

The evidence for old drugs against cancer is scattered across hundreds of papers. Assembling it into the format regulators and funders need is cheap and would speed decisions.

## Summary

The Anticancer Fund's ReDO_DB and similar efforts catalogue candidates but stop short of the structured, regulator-grade dossiers (preclinical summary, pharmacology, safety in the target population, systematic review of clinical signals, proposed trial design) that a funder or a third-party label filing needs. The proposal is a funded programme, with methodologists and regulatory writers, that produces and publishes open dossiers for the 20 candidates with the strongest evidence, updated annually, each ending with a prioritised trial proposal and a regulatory strategy.

## Fields

- Kind: Idea
- Last checked: 2026-09-08
- Hypothesis: Within three years, at least half of the dossiers lead to a funded trial or a regulatory or guideline submission, compared with a small minority of candidates in the current catalogue.
- Rationale: Funders and regulators act on well-organised evidence; the marginal cost of a dossier is trivial against the cost of the trial it enables, and public dossiers prevent duplicated effort across countries.
- Proposed test: Produce the first ten dossiers, circulate to funders and regulators, and track downstream trial funding and submissions against ten matched candidates without dossiers.
- Maturity: early-clinical
- Actor: philanthropy

## Sources

- ReDO_DB (page moved; nearest live section): https://www.anticancerfund.org/en/

## Connected records

- bottlenecks: [Knowledge reaches practice too slowly](https://onco.cc/bottlenecks/b-knowledge-diffusion/), [No incentive to repurpose cheap drugs](https://onco.cc/bottlenecks/b-generic-repurposing/)

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