# Givinostat

Source: https://onco.cc/drugs/givinostat/  
OnCo record `givinostat` (Treatment). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Givinostat is an experimental small-molecule drug from Italfarmaco in phase 3 trials for myeloproliferative neoplasms, with its target not yet stated publicly.

## Summary

Givinostat (ITF2357) is a small-molecule drug developed by Italfarmaco. Its molecular target is not stated in the ClinicalTrials.gov intervention record, and OnCo has not confirmed one from the sponsor's pipeline page. ClinicalTrials.gov describes the intervention as: Patients will continue at their last tolerable dose and treatment schedule of givinostat monotherapy. Givinostat is a histone-deacetylases inhibitor. The product will be supplied as hard gelatine capsules for oral administration at the stre. It is the investigational product in 2 recruiting or active industry-led phase 2 and phase 3 interventional cancer trials, including the phase 3 study NCT06093672 (Study on Efficacy and Safety of Givinostat Versus Hydroxyurea in Patients With Polycythemia Vera), in myeloproliferative neoplasms. The largest, NCT06093672, plans to enrol 220 participants with primary completion was scheduled for 2026-07 on the registry. Status reflects the highest phase registered on ClinicalTrials.gov; no efficacy results are recorded here.

## Fields

- Kind: Treatment
- Status: phase-3
- Last checked: 2026-09-11
- Also known as: givinostat (ITF2357)
- Tags: pipeline; ctgov-ingest
- Code: ITF2357
- Modality: small molecule
- Mechanism: Mechanism not stated in the ClinicalTrials.gov record or on the sponsor's pipeline page.

## Sources

- ClinicalTrials.gov: trials of Givinostat: https://clinicaltrials.gov/search?intr=ITF2357
- Sponsor page: https://www.italfarmaco.com

## Connected records

- cancers: [Myeloproliferative neoplasms (PV, ET, myelofibrosis)](https://onco.cc/cancers/myeloproliferative-neoplasms/), [Polycythaemia vera (PV)](https://onco.cc/cancers/polycythaemia-vera/)
- companies: [Italfarmaco](https://onco.cc/companies/italfarmaco/)
- trials: [Long-term Study Evaluating the Effect of Givinostat in Patients With Chronic Myeloproliferative Neoplasms](https://onco.cc/trials/nct01761968/), [Study on Efficacy and Safety of Givinostat Versus Hydroxyurea in Patients With Polycythemia Vera](https://onco.cc/trials/nct06093672/)

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JSON: https://onco.cc/api/v1/entities/givinostat.json