# Hallmark: evading growth suppressors

Source: https://onco.cc/terms/evading-growth-suppressors/  
OnCo record `evading-growth-suppressors` (Term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Evading growth suppressors means cutting the brakes that normally stop division, p53 and RB above all.

## Summary

Evading growth suppressors is the hallmark of cutting the brakes that normally halt cell division, above all p53 and RB. The lesions are losses of TP53 (in half of cancers), RB1, CDKN2A (p16), PTEN, NF1 and APC, acting through the p53 / RB / cell-cycle checkpoint, Wnt / β-catenin and Hippo-YAP/TAZ pathways. Therapeutically, CDK4/6 inhibitors re-impose the RB brake, MDM2 inhibitors and p53 reactivators try to restore p53, and PTEN loss sensitises tumours to AKT inhibition, which is why TP53, CDK4/6 and AKT are the linked targets. Readers arrive here from the Hallmarks of Cancer overview and the 2000 hallmarks paper, from the Tumour suppressor gene entry, and from the p53 network and cell-cycle engine pathway pages.

## Fields

- Kind: Term
- Last checked: 2026-09-08
- Tags: hallmark

## Sources

- Wikipedia: https://en.wikipedia.org/wiki/The_Hallmarks_of_Cancer
- Hanahan, Hallmarks of Cancer: New Dimensions (Cancer Discovery 2022): https://doi.org/10.1158/2159-8290.CD-21-1059

## Connected records

- technologies: [CDK4/6 inhibitors](https://onco.cc/technologies/cdk46-inhibitor/)
- targets: [AKT](https://onco.cc/targets/akt/), [CDK4/6](https://onco.cc/targets/cdk4-6/), [TP53](https://onco.cc/targets/tp53/)
- pathways: [Hippo-YAP/TAZ](https://onco.cc/pathways/hippo-yap/), [p53 / RB / cell-cycle checkpoint](https://onco.cc/pathways/p53-cell-cycle/), [The cell-cycle engine (cyclins & CDKs)](https://onco.cc/pathways/cell-cycle-engine-cdks/), [The p53 network (guardian of the genome)](https://onco.cc/pathways/p53-mdm2-axis/), [Wnt / β-catenin](https://onco.cc/pathways/wnt/)
- terms: [Hallmarks of Cancer](https://onco.cc/terms/hallmarks-of-cancer/), [Hallmarks of cancer as a synthesis of the theories](https://onco.cc/terms/hallmarks-synthesis/), [Tumour suppressor gene](https://onco.cc/terms/tumour-suppressor-gene/)
- key papers: [The Hallmarks of Cancer: six capabilities every tumour must acquire](https://onco.cc/key-papers/paper-hallmarks-of-cancer-cell-2000/)

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