# Erik Sahai

Source: https://onco.cc/people/erik-sahai/  
OnCo record `erik-sahai` (Person). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Cell biologist studying how the tumour's surroundings help cancer cells invade and resist drugs.

## Summary

Erik Sahai is Principal Group Leader of the Tumour Cell Biology Laboratory at The Francis Crick Institute in London. His specialisms are the tumour microenvironment, cancer cell invasion, and drug resistance and plasticity, with an interest in the fibroblast marker FAP. He uses intravital imaging and computational models to study how fibroblasts interact with tumour cells, how cancer cells invade, and the non-genetic plasticity that lets them survive targeted therapy. His Nature Reviews Cancer paper set out a framework for understanding cancer-associated fibroblasts. His work explains how a tumour's surroundings help it spread and resist drugs. His publications are listed on PubMed.

## Fields

- Kind: Person
- Last checked: 2026-09-08
- Role: Principal Group Leader, Tumour Cell Biology Laboratory, Francis Crick Institute
- Specialisms: Tumour microenvironment; Cancer cell invasion; Drug resistance and plasticity

## Sources

- PubMed: https://pubmed.ncbi.nlm.nih.gov/?term=Sahai%20E%5BAuthor%5D%20tumour%20microenvironment

## Connected records

- targets: [FAP](https://onco.cc/targets/fap/)
- institutions: [The Francis Crick Institute](https://onco.cc/institutions/francis-crick/)
- pathways: [Epithelial-mesenchymal transition & drug efflux](https://onco.cc/pathways/emt/)
- journals: [Nature Reviews Cancer](https://onco.cc/journals/nature-reviews-cancer/)
- ideas: [Break the neutrophil DNA nets that catch tumour cells after surgery](https://onco.cc/ideas/idea-bio2-net-blockade-perioperative/), [Match therapy to the type of scar-forming cell in the tumour](https://onco.cc/ideas/idea-bio2-caf-subtype-assignment/), [Soften the tissue that new metastases need in order to grow](https://onco.cc/ideas/idea-bio2-matrix-stiffness-prevention/)

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