# EndoPredict

Source: https://onco.cc/drugs/endopredict/  
OnCo record `endopredict` (Treatment). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A 12-gene test that combines gene activity with tumour size and lymph nodes to say whether hormone therapy alone is enough, and whether to continue it beyond five years.

## Summary

EndoPredict (Sividon, acquired by Myriad Genetics in 2016) is CE-marked and validated in the ABCSG-6 and ABCSG-8 trial cohorts and in TransATAC, where EPclin identified a low-risk group with about 4% distant recurrence at 10 years on endocrine therapy alone and predicted late recurrence between years five and ten. NICE DG34 recommends it for guiding chemotherapy decisions in the NHS; it is offered in the US as a laboratory-developed test. Because it includes clinical variables, EPclin outperformed purely molecular scores in head-to-head comparisons on the TransATAC cohort.

## Fields

- Kind: Treatment
- Status: established
- Last checked: 2026-09-10
- Tags: test
- Brand: EndoPredict
- Modality: Gene-expression prognostic assay (12-gene EPclin score)
- Mechanism: RT-PCR of eight cancer genes and three reference genes gives a molecular score, combined with tumour size and nodal status into the EPclin score predicting 10-year distant recurrence.

## Notes

- What a result means: EPclin low means chemotherapy can safely be omitted and the case for extended hormone therapy is weak; EPclin high means the opposite.

## Sources

- NICE DG34: https://www.nice.org.uk/guidance/dg34
- Myriad: EndoPredict: https://myriad.com/oncology/endopredict/

## Connected records

- drugs: [Breast Cancer Index](https://onco.cc/drugs/breast-cancer-index/), [Oncotype DX](https://onco.cc/drugs/oncotype-dx/), [Prosigna (PAM50)](https://onco.cc/drugs/prosigna/)
- cancers: [HR-positive / HER2-negative breast cancer](https://onco.cc/cancers/breast-hr-positive/)
- technologies: [RNA sequencing & expression profiling](https://onco.cc/technologies/rna-seq/)
- companies: [Myriad Genetics](https://onco.cc/companies/myriad-genetics/)

---
JSON: https://onco.cc/api/v1/entities/endopredict.json