# Daniel E. Spratt

Source: https://onco.cc/people/daniel-spratt/  
OnCo record `daniel-spratt` (Person). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Radiation oncologist who built AI models from trial slides to decide which prostate cancer patients need hormone therapy.

## Summary

Daniel Spratt led the development and validation of the ArteraAI multimodal AI prostate test using digitised pathology and clinical data from NRG/RTOG trials, the first AI biomarker to enter NCCN prostate guidelines. He has led analyses of the Decipher genomic classifier and chairs NRG GU trials of biomarker-guided treatment intensification and de-intensification.

## Fields

- Kind: Person
- Last checked: 2026-09-10
- Tags: prostate; ai; radiotherapy
- Role: Chair of Radiation Oncology, University Hospitals Seidman Cancer Center and Case Western Reserve University
- Specialisms: Prostate radiotherapy; AI biomarkers; Genomic classifiers; Cooperative-group trials

## Sources

- PubMed: https://pubmed.ncbi.nlm.nih.gov/?term=Spratt%20DE%5BAuthor%5D%20prostate%20artificial%20intelligence

## Connected records

- cancers: [Prostate cancer](https://onco.cc/cancers/prostate/)
- technologies: [Digital pathology & AI](https://onco.cc/technologies/digital-pathology-ai/), [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- drugs: [ArteraAI Prostate](https://onco.cc/drugs/artera-ai-prostate/)
- institutions: [Case Comprehensive Cancer Center](https://onco.cc/institutions/case-ccc/)
- journals: [NEJM Evidence](https://onco.cc/journals/nejm-evidence/)

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