# Crystal L. Mackall

Source: https://onco.cc/people/crystal-mackall/  
OnCo record `crystal-mackall` (Person). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Crystal Mackall is a cell therapy pioneer whose team brought GD2 CAR-T to children with brain tumours that had no treatment.

## Summary

Crystal Mackall is Director of the Stanford Center for Cancer Cell Therapy and Ernest and Amelia Gallo Family Professor at Stanford, within the Stanford Cancer Institute. A paediatric oncologist and immunologist, she leads Stanford's cancer cell therapy programme, whose GD2 CAR-T trial in H3K27M diffuse midline glioma produced the first meaningful responses in that disease. Her papers include the Nature report of GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas and a Nature study showing that c-Jun overexpression in CAR T cells induces exhaustion resistance. She studies CAR-T exhaustion and enhancement across glioma, neuroblastoma and sarcomas.

## Fields

- Kind: Person
- Last checked: 2026-09-08
- Role: Director, Stanford Center for Cancer Cell Therapy; Ernest and Amelia Gallo Family Professor
- Specialisms: CAR-T cell therapy; Paediatric oncology; Immunotherapy

## Sources

- Stanford profile: https://profiles.stanford.edu/search?q=Crystal%20L.%20Mackall
- PubMed: https://pubmed.ncbi.nlm.nih.gov/?term=Mackall%20CL%5BAuthor%5D
- Google Scholar: https://scholar.google.com/scholar?q=Crystal%20L.%20Mackall

## Connected records

- cancers: [Glioma & glioblastoma](https://onco.cc/cancers/glioblastoma/), [Neuroblastoma (paediatric)](https://onco.cc/cancers/neuroblastoma/), [Sarcomas (soft tissue, bone, GIST)](https://onco.cc/cancers/sarcoma/)
- technologies: [Armoured, logic-gated & next-gen CARs](https://onco.cc/technologies/armored-car/), [CAR-T cell therapy](https://onco.cc/technologies/car-t/)
- targets: [GD2 (disialoganglioside)](https://onco.cc/targets/gd2/)
- institutions: [Stanford Health Care / Stanford Cancer Institute](https://onco.cc/institutions/stanford/)
- terms: [H3 K27M (diffuse midline glioma)](https://onco.cc/terms/h3k27m/)
- trials: [GD2-CART01 (Bambino Gesù phase 1/2)](https://onco.cc/trials/gd2-cart01/)

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