# Chromogranin A

Source: https://onco.cc/terms/chromogranin-a/  
OnCo record `chromogranin-a` (Term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Chromogranin A is a protein released by neuroendocrine cells and measured in blood to follow tumour burden; it is unreliable because acid-reducing drugs and kidney disease also raise it.

## Summary

Chromogranin A is a protein released by neuroendocrine cells and measured in blood to follow tumour burden in neuroendocrine tumours. Its sensitivity for metastatic disease is variable, and it gives false positives with proton-pump inhibitors, renal impairment and atrophic gastritis, so a single value is hard to interpret. Following the trend over time is more useful than any one measurement. The NETest, a multi-gene blood transcript assay, has been proposed as a replacement. Readers meet the term on the neuroendocrine tumours page, and it matters because acid-reducing drugs and kidney disease can raise it without any change in the cancer.

## Fields

- Kind: Term
- Last checked: 2026-09-07

## Sources

- Wikipedia: https://en.wikipedia.org/wiki/Chromogranin_A
- Wikipedia: https://en.wikipedia.org/wiki/Chromogranin_A

## Connected records

- cancers: [Grade 3 well-differentiated neuroendocrine tumour](https://onco.cc/cancers/grade-3-net/), [Lung neuroendocrine tumours (typical and atypical carcinoid)](https://onco.cc/cancers/lung-net/), [Neuroendocrine tumours](https://onco.cc/cancers/neuroendocrine/), [Pancreatic neuroendocrine tumours](https://onco.cc/cancers/pancreatic-net/), [Small intestinal neuroendocrine tumours](https://onco.cc/cancers/small-intestinal-net/)
- terms: [Urinary catecholamine metabolites (VMA and HVA)](https://onco.cc/terms/urinary-catecholamines/)
- technologies: [Serum tumour markers: proper use and misuse](https://onco.cc/technologies/serum-tumour-markers/)

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