# Charlotte E. Coles

Source: https://onco.cc/people/charlotte-coles/  
OnCo record `charlotte-coles` (Person). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Led IMPORT LOW, which showed partial-breast radiotherapy is as effective as whole-breast treatment with fewer side effects.

## Summary

Charlotte Coles was chief investigator of IMPORT LOW, the UK trial showing partial-breast radiotherapy after breast conservation matches whole-breast radiotherapy for local control with less breast hardening, and co-led IMPORT HIGH and the PRIMETIME study of radiotherapy omission. She chaired the Lancet Breast Cancer Commission and is a leader in ESTRO. Her work drives the shift to shorter, more targeted breast radiotherapy.

## Fields

- Kind: Person
- Last checked: 2026-09-10
- Tags: radiotherapy; breast; de-escalation
- Role: Professor of Breast Cancer Clinical Oncology, University of Cambridge; Consultant, Addenbrooke's Hospital
- Specialisms: Breast radiotherapy; Partial breast irradiation; Hypofractionation; Radiotherapy de-escalation

## Sources

- Wikipedia: https://en.wikipedia.org/wiki/Charlotte_Coles
- PubMed: https://pubmed.ncbi.nlm.nih.gov/?term=Coles%20CE%5BAuthor%5D%20breast%20radiotherapy%20IMPORT

## Connected records

- cancers: [HR-positive / HER2-negative breast cancer](https://onco.cc/cancers/breast-hr-positive/)
- technologies: [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- institutions: [Cancer Research UK Cambridge Centre / CRUK Cambridge Institute](https://onco.cc/institutions/cruk-cambridge-centre/), [European Society for Radiotherapy and Oncology](https://onco.cc/institutions/estro/)

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