# Carlos Caldas

Source: https://onco.cc/people/carlos-caldas/  
OnCo record `carlos-caldas` (Person). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Led METABRIC, which used 2,000 tumours to define ten genomic subtypes of breast cancer and their long-term outcomes.

## Summary

Carlos Caldas led METABRIC, the integrated genomic and transcriptomic analysis of 2,000 breast cancers that defined ten integrative clusters with distinct 20-year outcomes, and the follow-up showing that late relapse risk differs sharply between them. His group built a large breast cancer PDX biobank for functional testing and studies the evolution of metastatic breast cancer. He led the Cambridge Breast Cancer Research Unit.

## Fields

- Kind: Person
- Last checked: 2026-09-10
- Tags: genomics; breast; classification
- Role: Professor of Cancer Medicine, University of Cambridge; Senior Group Leader, CRUK Cambridge Institute
- Specialisms: Breast cancer genomics; Integrative clusters; Patient-derived xenografts; Functional genomics

## Sources

- Wikipedia: https://en.wikipedia.org/wiki/Carlos_Caldas
- PubMed: https://pubmed.ncbi.nlm.nih.gov/?term=Caldas%20C%5BAuthor%5D%20breast%20genomic%20METABRIC

## Connected records

- cancers: [HER2-positive breast cancer](https://onco.cc/cancers/breast-her2-positive/), [HR-positive / HER2-negative breast cancer](https://onco.cc/cancers/breast-hr-positive/), [Triple-negative breast cancer (TNBC)](https://onco.cc/cancers/tnbc/)
- technologies: [Patient-derived xenografts](https://onco.cc/technologies/pdx-models/), [RNA sequencing & expression profiling](https://onco.cc/technologies/rna-seq/), [Whole-exome & whole-genome sequencing](https://onco.cc/technologies/wes-wgs/)
- institutions: [Cancer Research UK Cambridge Centre / CRUK Cambridge Institute](https://onco.cc/institutions/cruk-cambridge-centre/)

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