# CD20 bispecific + CD79b ADC (mosunetuzumab + polatuzumab)

Source: https://onco.cc/pairings/bispecific-plus-adc-lymphoma/  
OnCo record `bispecific-plus-adc-lymphoma` (Pairing). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Pairing a CD20 bispecific with a CD79b ADC lets two targeted drugs with different mechanisms replace chemotherapy in relapsed lymphoma.

## Summary

This combination pairs the CD20 bispecific antibody mosunetuzumab with the CD79b antibody-drug conjugate polatuzumab vedotin in relapsed diffuse large B-cell lymphoma, replacing chemotherapy with two targeted drugs of different mechanism. The ADC debulks the tumour, lowering antigen load and with it the risk of cytokine release syndrome, and the bispecific then consolidates through T-cell killing; the toxicities of the two do not overlap. The phase 3 SUNMO trial, reported in 2025, was positive for progression-free survival against R-GemOx. The regimen is fixed-duration and can be given as an outpatient, and it sits alongside the EPCORE NHL-1 paper on epcoritamab as part of the shift to bispecific-based treatment in relapsed large B-cell lymphoma.

## Fields

- Kind: Pairing
- Last checked: 2026-09-07
- Pairs: Mosunetuzumab + Polatuzumab vedotin
- Type: combination
- Rationale: ADC debulks and reduces antigen load and CRS risk; bispecific consolidates with T-cell killing. Their toxicities do not overlap.
- Evidence: Phase 3 positive (PFS).

## Sources

- ClinicalTrials.gov NCT05171647: SUNMO: https://clinicaltrials.gov/study/NCT05171647

## Connected records

- cancers: [Diffuse large B-cell lymphoma](https://onco.cc/cancers/dlbcl/)
- trials: [SUNMO](https://onco.cc/trials/sunmo/)
- drugs: [Mosunetuzumab](https://onco.cc/drugs/mosunetuzumab/), [Polatuzumab vedotin](https://onco.cc/drugs/polatuzumab-vedotin/)
- key papers: [EPCORE NHL-1: epcoritamab, a subcutaneous CD20 x CD3 bispecific, in relapsed large B-cell lymphoma including after CAR-T](https://onco.cc/key-papers/paper-epcore-nhl-1-epcoritamab-jco-2023/)

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