# Benjamin Besse

Source: https://onco.cc/people/benjamin-besse/  
OnCo record `benjamin-besse` (Person). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Benjamin Besse is a lung cancer trialist central to the Dato-DXd and HER3-DXd lung programmes.

## Summary

Benjamin Besse is Head of Clinical Research at Gustave Roussy and a thoracic oncologist. His specialisms are thoracic oncology, antibody-drug conjugates in lung cancer and oncogene-driven non-small-cell lung cancer. He is a principal investigator in the TROPION-Lung and HERTHENA-Lung programmes, which test datopotamab deruxtecan and patritumab deruxtecan in lung cancer, and in trials of targeted therapy for oncogene-driven disease. His Journal of Clinical Oncology paper on TROPION-Lung01 compared datopotamab deruxtecan with docetaxel in previously treated advanced or metastatic non-small-cell lung cancer. He is linked to the TROPION-Lung01 and HERTHENA-Lung02 trials, and his publications are listed on PubMed.

## Fields

- Kind: Person
- Last checked: 2026-09-08
- Role: Head of Clinical Research, Gustave Roussy; thoracic oncologist
- Specialisms: Thoracic oncology; ADCs in lung cancer; Oncogene-driven NSCLC

## Sources

- PubMed: https://pubmed.ncbi.nlm.nih.gov/?term=Besse%20B%5BAuthor%5D%20lung%20deruxtecan

## Connected records

- cancers: [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)
- drugs: [Datopotamab deruxtecan](https://onco.cc/drugs/datopotamab-deruxtecan/), [Patritumab deruxtecan](https://onco.cc/drugs/patritumab-deruxtecan/)
- institutions: [Gustave Roussy](https://onco.cc/institutions/gustave-roussy/)
- trials: [HERTHENA-Lung02](https://onco.cc/trials/herthena-lung02/), [TROPION-Lung01](https://onco.cc/trials/tropion-lung01/)
- key papers: [MARIPOSA: amivantamab plus lazertinib versus osimertinib as first treatment for EGFR-mutated lung cancer](https://onco.cc/key-papers/paper-mariposa-nejm-2024/)
- companies: [Intergroupe Francophone de Cancérologie Thoracique](https://onco.cc/companies/ifct/)

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