# Arc Institute

Source: https://onco.cc/institutions/arc-institute/  
OnCo record `arc-institute` (Institution). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

The Arc Institute is a well-funded nonprofit research institute building 'virtual cell' AI models and the datasets to train them.

## Summary

The Arc Institute in Palo Alto is a well-funded nonprofit research institute founded in 2021 with Stanford, UCSF and Berkeley affiliations, building virtual cell AI models and the datasets needed to train them. It is home to the Evo and Evo 2 genome language models built with NVIDIA, the State perturbation-response model, the Arc Virtual Cell Atlas and the Tahoe-100M dataset, and it ran the Virtual Cell Challenge in 2025; its scale of perturbation data collection is unusual for an academic institute, and Silvana Konermann is among the people linked. OnCo connects it to the Chan Zuckerberg Biohub and to the virtual cell roadmap that runs from bulk omics to a predictive model of a cancer cell. Whether perturbation-trained models predict responses in patients, not just cell lines, is the open question. Its Evo, State and Virtual Cell Atlas programmes are listed below.

## Fields

- Kind: Institution
- Last checked: 2026-09-08
- Tags: ai; virtual-cell
- City: Palo Alto, CA, US
- Type: research-institute
- Website: https://arcinstitute.org

## Sources

- Wikipedia: https://en.wikipedia.org/wiki/Arc_Institute
- Official website: https://arcinstitute.org

## Connected records

- fronts: [AI & Computation](https://onco.cc/fronts/ai-computation/), [Drug Discovery Platforms](https://onco.cc/fronts/drug-discovery/)
- technologies: [Evo 2 (Arc Institute, NVIDIA)](https://onco.cc/technologies/evo2/), [State (Arc Institute perturbation model)](https://onco.cc/technologies/state-arc/)
- people: [Silvana Konermann](https://onco.cc/people/silvana-konermann/)
- institutions: [Chan Zuckerberg Biohub](https://onco.cc/institutions/cz-biohub/)
- collections: [Arc Virtual Cell Atlas](https://onco.cc/collections/arc-virtual-cell-atlas/), [Tahoe-100M](https://onco.cc/collections/tahoe-100m/)
- roadmaps: [Drug discovery roadmap: screening in mice → maps of dependency → designing in silico](https://onco.cc/roadmaps/drug-discovery-roadmap/), [Virtual cell roadmap: from bulk omics to a predictive model of a cancer cell](https://onco.cc/roadmaps/virtual-cell/)

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JSON: https://onco.cc/api/v1/entities/arc-institute.json