# Anvumetostat

Source: https://onco.cc/drugs/anvumetostat/  
OnCo record `anvumetostat` (Treatment). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Anvumetostat is an experimental small-molecule drug from Amgen in phase 2 trials for non-small-cell lung cancer, aimed at PRMT5 (MTAP-deleted cancers).

## Summary

Anvumetostat is a small-molecule drug developed by Amgen. Its target is PRMT5 (MTAP-deleted cancers). The sponsor states: Anvumetostat (AMG 193) is an MTA-cooperative PRMT5 inhibitor, formulated as an oral film-coated tablet, studied in MTAP-deleted/null advanced NSCLC and other solid tumours. It is the investigational product in 2 recruiting or active industry-led phase 2 and phase 3 interventional cancer trials, in non-small-cell lung cancer. The largest, NCT05094336, plans to enrol 329 participants (actual) with primary completion expected 2026-11-30. Status reflects the highest phase registered on ClinicalTrials.gov; no efficacy results are recorded here.

## Fields

- Kind: Treatment
- Status: phase-2
- Last checked: 2026-09-11
- Also known as: MTA Cooperative PRMT5 inhibitor; AMG 193
- Tags: pipeline; ctgov-ingest
- Modality: small molecule
- Mechanism: Anvumetostat (AMG 193) is an MTA-cooperative PRMT5 inhibitor, formulated as an oral film-coated tablet, studied in MTAP-deleted/null advanced NSCLC and other solid tumours.

## Sources

- ClinicalTrials.gov: trials of Anvumetostat: https://clinicaltrials.gov/search?intr=Anvumetostat

## Connected records

- cancers: [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)
- targets: [PRMT5 (MTAP-deleted cancers)](https://onco.cc/targets/prmt5-mtap/)
- companies: [Amgen](https://onco.cc/companies/amgen/)
- trials: [A Phase 2 Study of Anvumetostat in Participants With MTAP-deleted Advanced NSCLC (MTAPESTRY 201)](https://onco.cc/trials/nct06593522/), [A Study of Anvumetostat in Participants With Advanced MTAP-null Solid Tumors (MTAPESTRY 101)](https://onco.cc/trials/nct05094336/)

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