# Andrew J. Aguirre

Source: https://onco.cc/people/andrew-aguirre/  
OnCo record `andrew-aguirre` (Person). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Uses organoids and functional genomics to find what pancreatic cancers depend on beyond KRAS.

## Summary

Andrew J. Aguirre is an Institute Member at the Broad Institute of MIT and Harvard and a physician at Dana-Farber, working on pancreatic ductal adenocarcinoma and KRAS biology. He is known for leading real-time genomic profiling of advanced pancreatic cancer to enable precision medicine, the subject of his selected paper. His laboratory uses patient-derived organoids and functional genomics to find what pancreatic cancers depend on beyond KRAS. He now studies RAS-pathway dependencies and resistance to KRAS and RAS inhibitors.

## Fields

- Kind: Person
- Last checked: 2026-09-08
- Role: Institute Member, Broad; Physician, Dana-Farber
- Specialisms: Pancreatic cancer; KRAS biology; Organoids

## Sources

- PubMed: https://pubmed.ncbi.nlm.nih.gov/?term=Aguirre%20AJ%5BAuthor%5D

## Connected records

- cancers: [KRAS G12C-mutant pancreatic ductal adenocarcinoma](https://onco.cc/cancers/kras-g12c-pdac/), [Pancreatic ductal adenocarcinoma](https://onco.cc/cancers/pancreatic/)
- technologies: [KRAS & RAS inhibitors](https://onco.cc/technologies/kras-inhibitors/), [Patient-derived organoids](https://onco.cc/technologies/organoids/)
- targets: [KRAS](https://onco.cc/targets/kras/)
- institutions: [Broad Institute of MIT and Harvard](https://onco.cc/institutions/broad-institute/), [Lustgarten Foundation](https://onco.cc/institutions/lustgarten-foundation/)
- key papers: [Germline cancer susceptibility gene variants, somatic second hits, and survival outcomes in patients with resected pancreatic cancer](https://onco.cc/key-papers/paper-yurgelun-germline-second-hits-resected-pancreatic-genet-med-2019/), [Integrated genomic characterization of pancreatic ductal adenocarcinoma](https://onco.cc/key-papers/paper-tcga-pancreatic-integrated-characterisation-cancer-cell-2017/), [Real-time genomic characterization of advanced pancreatic cancer to enable precision medicine](https://onco.cc/key-papers/paper-aguirre-real-time-genomic-characterisation-pancreatic-cancer-discov-2018/)

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